PXD019693

PXD019693 is an original dataset announced via ProteomeXchange.

Title	The implications of taphonomic alteration of human bone protein profiles for the development of a bone proteomics PMI/AAD estimation method.
Description	The estimation of the post-mortem interval (PMI) and the age-at-death (AAD) are crucial steps in the medico-legal investigation of unidentified human remains. Current methods to estimate PMI and AAD suffer from a lack of accuracy and objectivity, particularly when the remains are in an advanced state of decomposition. Recently, proteomics studies using animal models have identified potential biomarkers for PMI and AAD estimation. This study investigated the human bone proteome in four human body donors studied throughout decomposition outdoors. We compared different bone tissues (tibia and iliac crest) from body donors of known AAD, and compared bone samples taken shortly after death to bone samples upon complete skeletonization of the body. The effects of ageing phenomena (in vivo and post-mortem) and the surrounding environment on the variability and abundancy of the bone proteome were assessed.
HostingRepository	PRIDE
AnnounceDate	2021-09-09
AnnouncementXML	Submission_2021-09-09_03:39:31.637.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD019693
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Noemi Procopio
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-06-10 03:45:26	ID requested
⏵ 1	2021-09-09 03:39:32	announced

Mickleburgh HL, Schwalbe EC, Bonicelli A, Mizukami H, Sellitto F, Starace S, Wescott DJ, Carter DO, Procopio N, Human Bone Proteomes before and after Decomposition: Investigating the Effects of Biological Variation and Taphonomic Alteration on Bone Protein Profiles and the Implications for Forensic Proteomics. J Proteome Res, 20(5):2533-2546(2021) [pubmed]

submitter keyword: Forensic proteomics, bone proteomics, taphonomy, post-mortem interval, chronological ageing

Noemi Procopio
contact affiliation	The Forensic Science Unit, Faculty of Health and Life Sciences, Ellison Building, Northumbria University, Newcastle Upon Tyne, UK
contact email	noemi.procopio@northumbria.ac.uk
lab head
Noemi Procopio
contact affiliation	Northumbria University
contact email	noemi.procopio@northumbria.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD019693
     1. Label: PRIDE project
     2. Name: The implications of taphonomic alteration of human bone protein profiles for the development of a bone proteomics PMI/AAD estimation method.