PXD019685
PXD019685 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic portraits of human and porcine spinal cord injury define cross-species biomarkers of injury severity and recovery |
| Description | Despite the emergence of promising therapeutic approaches in preclinical studies, the failure of large-scale clinical trials leaves clinicians without effective treatments for acute spinal cord injury (SCI). These trials are hindered by their reliance on detailed neurological examinations to establish outcomes, which inflate the time and resources required for completion. Moreover, therapeutic development takes place in animal models whose relevance to human injury remains unclear. Here, we address these challenges through targeted proteomic analyses of CSF and serum samples from 111 acute SCI patients and, in parallel, a large animal (porcine) model of SCI. We develop and validate protein biomarkers of injury severity and recovery, including a prognostic model of neurological improvement at six months with an AUC of 0.91. Through comparative proteomic analyses, we dissect conserved and divergent aspects of the SCI response, and establish the CSF abundance of glial fibrillary acidic protein (GFAP) as a biochemical outcome measure in both human and pig. Our work defines new resources to catalyze translation by facilitating the evaluation of novel SCI therapies, while also providing a resource from which to direct future preclinical efforts. |
| HostingRepository | MassIVE |
| AnnounceDate | 2021-06-25 |
| AnnouncementXML | Submission_2021-06-25_12:19:22.056.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jason Rogalski |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; scientific name: Sus scrofa; common name: pig; NCBI TaxID: 9823; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | instrument model; 6490 Triple Quadrupole LC/MS |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2020-06-09 17:04:50 | ID requested | |
| ⏵ 1 | 2021-06-25 12:19:22 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: CSF, cross-species, spinal cord injury |
Contact List
| Dr. Brian K. Kwon | |
|---|---|
| contact affiliation | International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC |
| contact email | brian.kwon@ubc.ca |
| lab head | |
| Jason Rogalski | |
| contact affiliation | UBC |
| contact email | rogy@mail.ubc.ca |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000085567/ |
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