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PXD019679 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleGHB analogs confer neuroprotection through specific interaction with the CaMKII hub domain
DescriptionCa2+/calmodulin-dependent protein kinase II alpha (CaMK2A) is an emerging drug target incerebral ischemia for which limited therapeutic options exist. Here we show that small-molecule analogs of the brain metabolite gamma-hydroxybutyric acid (GHB) afford neuroprotection via interaction specifically with the CaMK2A hub domain. Identification of CaMK2A as the GHB analog target was achieved by homogenate photoaffinity labeling followed by quantitative proteomics
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterUlrike Leurs
SpeciesList scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationListbiotinylated residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-06-09 13:05:25ID requested
12021-07-22 03:48:54announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: QExactive HF, brain homogenate, affinity purification, photoaffinity labeling, rat
Contact List
Jesper V. Olsen
contact affiliationNovo Nordisk Foundation Center for Protein Research, University of Copenhagen (Denmark)
contact emailjesper.olsen@cpr.ku.dk
lab head
Ulrike Leurs
contact affiliationUniversity of Copenhagen, Denmark
contact emailulrike.leurs@gmail.com
dataset submitter
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