PXD019675
PXD019675 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Gut microbiota may underlie the predisposition of healthy individuals to COVID-19 |
| Description | The COVID-19 pandemic is spreading globally with high disparity in the susceptibility of the disease severity. Identification of the key underlying factors for this disparity is highly warranted. Here we describe constructing a proteomic risk score based on 20 blood proteomic biomarkers which predict the progression to severe COVID-19. We demonstrate that in our own cohort without infection, this proteomic risk score is positively associated with proinflammatory cytokines mainly among older, but not younger, individuals. We further discovered that a core set of gut microbiota could accurately predict the above proteomic biomarkers using a machine learning model, and that these gut microbiota features are highly correlated with proinflammatory cytokines. |
| HostingRepository | iProX |
| AnnounceDate | 2020-06-09 |
| AnnouncementXML | Submission_2022-03-06_21:38:22.467.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Ju-sheng Zheng |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | TripleTOF 5600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2020-06-09 08:50:21 | ID requested | |
| 1 | 2022-03-06 19:52:29 | announced | |
| 2 | 2022-03-06 21:33:49 | announced | 2022-03-07: Update publication information. |
| ⏵ 3 | 2022-03-06 21:38:23 | announced | 2022-03-07: Update publication information. 2022-03-07: Update information. |
Publication List
| Gou W, Yue L, Tang XY, Wu YY, Cai X, Shuai M, Miao Z, Fu Y, Chen H, Jiang Z, Wang J, Tian Y, Xiao C, Xiang N, Wu Z, Chen YM, Guo T, Zheng JS, Circulating Proteome and Progression of Type 2 Diabetes. J Clin Endocrinol Metab, 107(6):1616-1625(2022) [pubmed] |
Keyword List
| submitter keyword: Proteomics, gut microbiota |
Contact List
| Ju-sheng Zheng | |
|---|---|
| contact affiliation | Westlake University |
| contact email | zhengjusheng@westlake.edu.cn |
| lab head | |
| Ju-sheng Zheng | |
| contact affiliation | Westlake University |
| contact email | zhengjusheng@westlake.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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