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PXD019667

PXD019667 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleQuantitative proteomic analyses to reveal the key features of proteins in new onset Ankylosing spondylitis patients
DescriptionAnkylosing spondylitis (AS) is a chronic immune-mediated disease. Various immune cells play an essential role in the AS pathogenesis. However, the specific pathogenesis of AS has not been well understood. Proteomic profiles of peripheral blood mononuclear cells (PBMCs) were applied to reveal the specific pathogenesis of AS. Quantitative proteomic analyses were performed using liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based methods, to investigate the proteins profiling of PBMCs from new-onset AS patients (n=9) and healthy controls (n=9). We identified 782 differentially expressed proteins (DEPs) and 527 differentially phosphorylated proteins (DPPs) between AS patients and healthy controls. Subcellular location of DEPs and DPPs showed most of DEPs from cytoplasm (n=296, 38%), extracellular (n=141, 18%) and nucleus (n=114, 15%), respectively; most of DPPs from cytoplasm (n=37, 34%), nucleus (n=35, 32%) and plasma membrane (n=10, 9%), respectively. We further identified 89 proteins with both expression and phosphorylation differences. Functional annotation of the 89 differentially expressed and phosphorylated proteins enriched in antigen processing and presentation pathway. Four differentially expressed proteins with six phosphorylated position were found in antigen processing and presentation pathway. The differentially expressed and phosphorylated proteins may be helpful to uncover the pathogenesis of AS. The six AS-specific proteins may sever as candidate markers for AS diagnosis and new treatment targets.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:28:35.414.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYongping Lu
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue
InstrumentQ Exactive Plus
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-06-09 06:09:39ID requested
12021-09-09 02:42:37announced
22024-10-22 05:28:41announced2024-10-22: Updated project metadata.
Publication List
10.1021/acsomega.0c01776;
Lu YP, Zhang XL, Zheng F, Yun C, Zhu C, Cai W, Liu D, Hong X, Li Q, Hu B, Tang D, Yin LH, Dai Y, Quantitative Proteomic Analyses To Reveal the Key Features of Proteins in New Onset Ankylosing Spondylitis Patients. ACS Omega, 5(32):20153-20161(2020) [pubmed]
Keyword List
submitter keyword: ankylosing spondylitis
peripheral blood mononuclear cells
proteomic
phosphoromics
Contact List
Yong Dai
contact affiliationThe First Affiliated Hospital of Southern University of Science and Technology, the Second Clinical Medical College of Jinan University, Shenzhen People’s Hospital, Shenzhen 518020, China
contact emaildaiyong22@aliyun.com
lab head
Yongping Lu
contact affiliationDepartment of Nephrology, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, China
contact email1057395831@qq.com
dataset submitter
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Dataset FTP location
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PRIDE project URI
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