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PXD019643

PXD019643 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe HLA-Ligand-Atlas. A resource of natural HLA ligands presented on benign tissues
DescriptionThe human leukocyte antigen (HLA) complex regulates the adaptive immune response by showcasing the intracellular and extracellular protein content to the immune system. T cells recognize these HLA-presented peptides as self or foreign and can elicit an immune response. In this work, we describe the HLA-Ligand-Atlas, a comprehensive map of HLA-I and HLA-II-presented peptides from 30 benign tissues, 51 HLA-I alleles, and 86 HLA-II alleles. Nearly 50% of HLA ligands have not been previously described. Due to the scarcity of benign human samples, the tissue was extracted from different organs at autopsy from human subjects without any diagnosed malignancy. Furthermore, we were able to identify non-canonical HLA-I peptides on benign tissues, showing that their processing is not unique to cancer. This dataset holds great promise in answering both basic and translational questions in fields such as autoimmunity, organ/tissue transplantation, and cancer immunotherapy.
HostingRepositoryPRIDE
AnnounceDate2021-04-16
AnnouncementXMLSubmission_2021-04-18_22:00:45.382.xml
DigitalObjectIdentifierhttp://dx.doi.org/10.6019/PXD019643
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterAna Marcu
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-06-08 04:44:10ID requested
12021-04-16 06:37:36announced
22021-04-18 22:00:46announced2021-04-19: Updated publication reference for PubMed record(s): 33858848.
Publication List
Marcu A, Bichmann L, Kuchenbecker L, Kowalewski DJ, Freudenmann LK, Backert L, Mühlenbruch L, Szolek A, Lübke M, Wagner P, Engler T, Matovina S, Wang J, Hauri-Hohl M, Martin R, Kapolou K, Walz JS, Velz J, Moch H, Regli L, Silginer M, Weller M, Löffler MW, Erhard F, Schlosser A, Kohlbacher O, Stevanović S, Rammensee HG, Neidert MC, HLA Ligand Atlas: a benign reference of HLA-presented peptides to improve T-cell-based cancer immunotherapy. J Immunother Cancer, 9(4):(2021) [pubmed]
Keyword List
submitter keyword: Human, HLA, Immunopeptidomics, Benign Tissues
Contact List
Hans-Georg Rammensee
contact affiliationDepartment of Immunology, Interfaculty Institute for Cell Biology, Eberhard Karls University Tübingen
contact emailhgrhgr2017@gmx.de
lab head
Ana Marcu
contact affiliationUniversity of Tübingen, Interfaculty Institute for Cell Biology, Department of Immunology
contact emailanamarcu.pe@gmail.com
dataset submitter
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Dataset FTP location
PRIDE project URI
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