PXD019571

PXD019571 is an original dataset announced via ProteomeXchange.

Title	GPX4-dependent Glutathione (GSH) high consumption drives platinum chemotherapeutic resistance by inhibiting ferroptosis in lung cancer derived brain metastasis
Description	Platinum-based chemotherapy is effective in inducing shrinkage of primary lung cancer lesions; however, it shows limited therapeutic efficacy in patients with brain metastasis (BM). In this study, we utilized a BM model of PC9 lung adenocarcinoma cells and found that the derivative brain metastatic subpopulations (PC9-BrMs) of parental cells PC9 developed obvious resistance to platinum; this suggested that the acquisition of chemo-resistance by brain metastatic cells is attributable to the intrinsic changes in the metastatic cells. Therefore, we performed an integrated profiling of metabolomics and proteomics, and described a radically altered spectrum of BM metabolism and protein expression compared with primary lung cancer cells. We identified a unique metabolite status characterized by high consumption of glutathione (GSH) for antioxidant stress response, both in BM cells and clinical serum samples.
HostingRepository	PRIDE
AnnounceDate	2022-02-16
AnnouncementXML	Submission_2022-02-16_04:00:39.366.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Qi Wang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2020-06-04 04:29:49	ID requested
⏵ 1	2022-02-16 04:00:40	announced

Liu W, Zhou Y, Duan W, Song J, Wei S, Xia S, Wang Y, Du X, Li E, Ren C, Wang W, Zhan Q, Wang Q, Glutathione peroxidase 4-dependent glutathione high-consumption drives acquired platinum chemoresistance in lung cancer-derived brain metastasis. Clin Transl Med, 11(9):e517(2021) [pubmed]

submitter keyword: lung cancer

brain metastasis

chemotherapeutic resistance

ferroptosis

glutathione metabolism

GPX4

Qi Wang
contact affiliation	The Second Hospital of Dalian Medical University
contact email	wqdlmu@163.com
lab head
Qi Wang
contact affiliation	The Second Hospital of Dalian Medical University
contact email	wqdlmu@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD019571

PRIDE project URI

• PRIDE
  1. PXD019571
     1. Label: PRIDE project
     2. Name: GPX4-dependent Glutathione (GSH) high consumption drives platinum chemotherapeutic resistance by inhibiting ferroptosis in lung cancer derived brain metastasis