PXD019547

PXD019547 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Uveal melanoma-derived extracellar vesicles displayed transforming potential and carried portein cargo involved in metastatic niche preparation
Description	Extracellular Vesicles (EVs) are oval membrane-enclosed structures with highlyheterogeneous content. EVs are known to play important roles in intercellular communication by transporting their contents between cells whereby they alter the properties of both donor and recipient cells.Uveal melanoma (UM) is the most common primary intraoculartumor in adults andit displays a high frequency of metastases to the liver. The aim of this study was to characterize the protein signature, determine the potential biomarker of circulating EVs derived from UM cell lines.Mass spectrometry of proteins from UM-EVs was performed and shwed the presence of exosomal markers and proteins involved in cell-cell and focal adhesion. In addition, we observed high expression of HSP70, HSP90 and integrin alpha V.
HostingRepository	PRIDE
AnnounceDate	2025-06-19
AnnouncementXML	Submission_2025-06-19_09:06:43.560.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Thupten Tsering
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetic acid derivatized residue; deamidated residue
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2020-06-03 14:59:58	ID requested
⏵ 1	2025-06-19 09:06:44	announced

Publication List

10.3390/cancers12102923;
Tsering T, Laskaris A, Abdouh M, Bustamante P, Parent S, Jin E, Ferrier ST, Arena G, Burnier JV, Uveal Melanoma-Derived Extracellular Vesicles Display Transforming Potential and Carry Protein Cargo Involved in Metastatic Niche Preparation. Cancers (Basel), 12(10):(2020) [pubmed]

10.3390/cancers12102923;

Tsering T, Laskaris A, Abdouh M, Bustamante P, Parent S, Jin E, Ferrier ST, Arena G, Burnier JV, Uveal Melanoma-Derived Extracellular Vesicles Display Transforming Potential and Carry Protein Cargo Involved in Metastatic Niche Preparation. Cancers (Basel), 12(10):(2020) [pubmed]

Keyword List

submitter keyword: liver metastasis, mass spectrometry, extracellular vesicles,Uveal melanoma

submitter keyword: liver metastasis, mass spectrometry, extracellular vesicles,Uveal melanoma

Contact List

Julia Burnier
contact affiliation	Assistant Professor, Oncology and Pathology McGill University Health Centre Research Institute Cancer Research Program MUHC Glen Site 1001 Decarie Boulevard Montreal, Quebec H4A 3J1
contact email	julia.burnier@mcgill.ca
lab head
Thupten Tsering
contact affiliation	RI-MUHC
contact email	thupten.tsering@mail.mcgill.ca
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD019547
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD019547

PRIDE project URI

Repository Record List

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