PXD019530

PXD019530 is an original dataset announced via ProteomeXchange.

Title	Molecular determinant for MED1 interaction with the VDR-RXR heterodimer
Description	To provide structural insights into the mechanism of the specific association of the coactivator MED1 with the Vitamin D nuclear (VDR)-RXR heterodimer, we used combined structural methods including X-ray crystallography, small angle X-ray scattering (SAXS), NMR, hydrogen-deuterium exchange coupled to mass spectrometry (HDX-MS), crosslinking mass spectrometry as well as biophysical methods.
HostingRepository	PRIDE
AnnounceDate	2021-02-11
AnnouncementXML	Submission_2021-02-10_23:06:34.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Maxime BOURGUET
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue
Instrument	SYNAPT G2-Si; Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2020-06-02 18:24:17	ID requested
1	2021-02-10 09:25:40	announced
⏵ 2	2021-02-10 23:06:35	announced	2021-02-11: Updated project metadata.

Belorusova AY, Bourguet M, Hessmann S, Chalhoub S, Kieffer B, Cianf, é, rani S, Rochel N, Molecular determinants of MED1 interaction with the DNA bound VDR-RXR heterodimer. Nucleic Acids Res, 48(19):11199-11213(2020) [pubmed]

10.1093/NAR/GKAA775;

submitter keyword: Nuclear receptor, VDR-RXR, HDX-MS, XL-MS

Sarah Cianferani
contact affiliation	LSMBO-IPHC CNRS
contact email	sarah.cianferani@unistra.fr
lab head
Maxime BOURGUET
contact affiliation	LSMBO - IPHC / CNRS
contact email	maxime.bourguet@etu.unistra.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/02/PXD019530

PRIDE project URI

• PRIDE
  1. PXD019530
     1. Label: PRIDE project
     2. Name: Molecular determinant for MED1 interaction with the VDR-RXR heterodimer