PXD019519 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Bioactivatable inhibitor of ubiquitin-dependent proteasomal degradation |
Description | The hyperactive state of malignant cells results in the production of an excess of aberrant proteins that challenge the clearing capacity of the ubiquitin-proteasome system (UPS), resulting in an increased sensitivity towards drugs that reduce the efficacy of this critical proteolytic system. In this project we report the identification of an inhibitor that subsequent to cellular metabolism inhibits the UPS. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:30:02.045.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Rozbeh Jafari |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-06-02 02:44:04 | ID requested | |
1 | 2021-11-03 04:58:30 | announced | |
⏵ 2 | 2024-10-22 05:30:02 | announced | 2024-10-22: Updated project metadata. |
Publication List
Giovannucci TA, Salomons FA, Haraldsson M, Elfman LHM, Wickstr, ö, m M, Young P, Lundb, ä, ck T, Eirich J, Altun M, Jafari R, Gustavsson AL, Johnsen JI, Dantuma NP, Inhibition of the ubiquitin-proteasome system by an NQO1-activatable compound. Cell Death Dis, 12(10):914(2021) [pubmed] |
10.1038/s41419-021-04191-9; |
Keyword List
submitter keyword: pulldown, click-chemistry, UPS, UPR,LC-MSMS |
Contact List
Janne Lehtiö |
contact affiliation | Department of Oncology-Pathology (OnkPat) (lab head) |
contact email | janne.lehtio@ki.se |
lab head | |
Rozbeh Jafari |
contact affiliation | Karolinska Institutet |
contact email | rozbeh.jafari@ki.se |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/11/PXD019519 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD019519
- Label: PRIDE project
- Name: Bioactivatable inhibitor of ubiquitin-dependent proteasomal degradation