PXD019519

PXD019519 is an original dataset announced via ProteomeXchange.

Title	Bioactivatable inhibitor of ubiquitin-dependent proteasomal degradation
Description	The hyperactive state of malignant cells results in the production of an excess of aberrant proteins that challenge the clearing capacity of the ubiquitin-proteasome system (UPS), resulting in an increased sensitivity towards drugs that reduce the efficacy of this critical proteolytic system. In this project we report the identification of an inhibitor that subsequent to cellular metabolism inhibits the UPS.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:30:02.045.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rozbeh Jafari
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-06-02 02:44:04	ID requested
1	2021-11-03 04:58:30	announced
⏵ 2	2024-10-22 05:30:02	announced	2024-10-22: Updated project metadata.

Giovannucci TA, Salomons FA, Haraldsson M, Elfman LHM, Wickstr, ö, m M, Young P, Lundb, ä, ck T, Eirich J, Altun M, Jafari R, Gustavsson AL, Johnsen JI, Dantuma NP, Inhibition of the ubiquitin-proteasome system by an NQO1-activatable compound. Cell Death Dis, 12(10):914(2021) [pubmed]

10.1038/s41419-021-04191-9;

submitter keyword: pulldown, click-chemistry, UPS, UPR,LC-MSMS

Janne Lehtiö
contact affiliation	Department of Oncology-Pathology (OnkPat) (lab head)
contact email	janne.lehtio@ki.se
lab head
Rozbeh Jafari
contact affiliation	Karolinska Institutet
contact email	rozbeh.jafari@ki.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/11/PXD019519

PRIDE project URI

• PRIDE
  1. PXD019519
     1. Label: PRIDE project
     2. Name: Bioactivatable inhibitor of ubiquitin-dependent proteasomal degradation