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PXD019519

PXD019519 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleBioactivatable inhibitor of ubiquitin-dependent proteasomal degradation
DescriptionThe hyperactive state of malignant cells results in the production of an excess of aberrant proteins that challenge the clearing capacity of the ubiquitin-proteasome system (UPS), resulting in an increased sensitivity towards drugs that reduce the efficacy of this critical proteolytic system. In this project we report the identification of an inhibitor that subsequent to cellular metabolism inhibits the UPS.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:30:02.045.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterRozbeh Jafari
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-06-02 02:44:04ID requested
12021-11-03 04:58:30announced
22024-10-22 05:30:02announced2024-10-22: Updated project metadata.
Publication List
Giovannucci TA, Salomons FA, Haraldsson M, Elfman LHM, Wickstr, ö, m M, Young P, Lundb, ä, ck T, Eirich J, Altun M, Jafari R, Gustavsson AL, Johnsen JI, Dantuma NP, Inhibition of the ubiquitin-proteasome system by an NQO1-activatable compound. Cell Death Dis, 12(10):914(2021) [pubmed]
10.1038/s41419-021-04191-9;
Keyword List
submitter keyword: pulldown, click-chemistry, UPS, UPR,LC-MSMS
Contact List
Janne Lehtiö
contact affiliationDepartment of Oncology-Pathology (OnkPat) (lab head)
contact emailjanne.lehtio@ki.se
lab head
Rozbeh Jafari
contact affiliationKarolinska Institutet
contact emailrozbeh.jafari@ki.se
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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