⮝ Full datasets listing

PXD019495

PXD019495 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTMT-proteomics of sorted MC38+ tumor cells with high-fat diet
DescriptionObesity is a major cancer risk factor, but the underlying molecular mechanisms are not always known. In this study, we look at proteome remodeling in cancer cells with obesity, comparing tumor cells sorted from mice fed high-fat versus control diet. We conducted 10-plex TMT-proteomics on GFP+ MC38 colorectal adenocarcinoma tumor cells, sorted from subcutaneously implanted tumors 12 days after implantation. This study reveals molecular pathways that change in cancer cells with obesity that promote tumor growth.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:16:48.428.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterBrandon Gassaway
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-06-01 08:51:11ID requested
12020-12-15 22:41:16announced
22024-10-22 05:16:49announced2024-10-22: Updated project metadata.
Publication List
Ringel AE, Drijvers JM, Baker GJ, Catozzi A, Garc, í, a-Ca, ñ, averas JC, Gassaway BM, Miller BC, Juneja VR, Nguyen TH, Joshi S, Yao CH, Yoon H, Sage PT, LaFleur MW, Trombley JD, Jacobson CA, Maliga Z, Gygi SP, Sorger PK, Rabinowitz JD, Sharpe AH, Haigis MC, Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity. Cell, 183(7):1848-1866.e26(2020) [pubmed]
10.1016/j.cell.2020.11.009;
Keyword List
submitter keyword: obesity, mouse,Biological, colorectal cancer
Contact List
Steven Gygi
contact affiliationHarvard University, Department of Cell Biology
contact emailsteven_gygi@hms.harvard.edu
lab head
Brandon Gassaway
contact affiliationHarvard Medical School
contact emailbrandon_gassaway@hms.harvard.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/12/PXD019495
PRIDE project URI
Repository Record List
[ + ]