PXD019495

PXD019495 is an original dataset announced via ProteomeXchange.

Title	TMT-proteomics of sorted MC38+ tumor cells with high-fat diet
Description	Obesity is a major cancer risk factor, but the underlying molecular mechanisms are not always known. In this study, we look at proteome remodeling in cancer cells with obesity, comparing tumor cells sorted from mice fed high-fat versus control diet. We conducted 10-plex TMT-proteomics on GFP+ MC38 colorectal adenocarcinoma tumor cells, sorted from subcutaneously implanted tumors 12 days after implantation. This study reveals molecular pathways that change in cancer cells with obesity that promote tumor growth.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:16:48.428.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Brandon Gassaway
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2020-06-01 08:51:11	ID requested
1	2020-12-15 22:41:16	announced
⏵ 2	2024-10-22 05:16:49	announced	2024-10-22: Updated project metadata.

Ringel AE, Drijvers JM, Baker GJ, Catozzi A, Garc, í, a-Ca, ñ, averas JC, Gassaway BM, Miller BC, Juneja VR, Nguyen TH, Joshi S, Yao CH, Yoon H, Sage PT, LaFleur MW, Trombley JD, Jacobson CA, Maliga Z, Gygi SP, Sorger PK, Rabinowitz JD, Sharpe AH, Haigis MC, Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity. Cell, 183(7):1848-1866.e26(2020) [pubmed]

10.1016/j.cell.2020.11.009;

submitter keyword: obesity, mouse,Biological, colorectal cancer

Steven Gygi
contact affiliation	Harvard University, Department of Cell Biology
contact email	steven_gygi@hms.harvard.edu
lab head
Brandon Gassaway
contact affiliation	Harvard Medical School
contact email	brandon_gassaway@hms.harvard.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/12/PXD019495

PRIDE project URI

• PRIDE
  1. PXD019495
     1. Label: PRIDE project
     2. Name: TMT-proteomics of sorted MC38+ tumor cells with high-fat diet