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PXD019481

PXD019481 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlePhosphoproteomic Effects of Acute Depletion of PP2A Regulatory Subunit Cdc55
DescriptionProtein phosphatase regulatory subunits are increasingly recognized as promising drug targets. In the absence of an existing drug, inducible degradation provides a means of predicting candidate targets. We here employed auxin-inducible degradation of S. cerevisiae PP2A regulatory subunit Cdc55 in combination with quantitative phosphoproteomics. A prevalence of hyperphosphorylated phosphopeptides and enrichment of proteins containing the PP2A consensus sequence indicates that the approach successfully identified direct PP2ACdc55 targets.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:13:29.684.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD019481
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterMichael Plank
SpeciesList scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932;
ModificationListphosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-06-01 01:07:07ID requested
12020-10-15 05:48:53announced
22024-10-22 05:13:30announced2024-10-22: Updated project metadata.
Publication List
Plank M, Berti M, Loewith R, Phosphoproteomic Effects of Acute Depletion of PP2A Regulatory Subunit Cdc55. Proteomics, 21(1):e2000166(2021) [pubmed]
10.1002/pmic.202000166;
Keyword List
submitter keyword: degron, protein phosphatase, SILAC, PP2A, phosphoproteomics,LC-MSMS
Contact List
Robbie Joseph Loewith
contact affiliationDepartment of Molecular Biology University of Geneva
contact emailrobbie.loewith@unige.ch
lab head
Michael Plank
contact affiliationUniversity of Arizona
contact emailmichael.plank@unige.ch
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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