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PXD019434 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDiscovery of biomarker candidates associated with the risk of short- and long-term relapse after infliximab withdrawal in Crohn’s patients: a proteomics-based study
DescriptionObjective: A subset of Crohn’s disease (CD) patients experiences long-term remission after infliximab withdrawal. Biomarkers are needed to identify those patients. Design: New biomarkers of relapse were searched in the baseline serum of CD patients stopping infliximab when they were under combined therapy (antimetabolite and infliximab) and stable clinical remission (STORI cohort, n=102). From shotgun proteomics experiment (discovery step), biomarker candidates were identified and further targeted by selected reaction monitoring (verification step). The dataset was stratified to search for markers of short- (<6 months) or long-term relapse (>6 months). The risk of relapse and the predicting capacity associated with biomarker candidates were evaluated using univariate Cox model and log-rank statistic, respectively. To test their complementary predicting capacity, biomarker candidates were systematically combined in pairs. Results: Distinct biomarker candidates were associated with the risk (hazard ratio: HR) of short- (15 proteins, 2.9
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterNicolas Pierre
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListCarbamidomethyl; Label:13C(6)15N(2)
InstrumentXevo TQ-S
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-05-27 21:54:54ID requested
12020-11-02 20:24:55announced
Publication List
Pierre N, Baiwir D, Huynh-Thu VA, Mazzucchelli G, Smargiasso N, De Pauw E, Bouhnik Y, Laharie D, Colombel JF, Meuwis MA, Louis E, Discovery of biomarker candidates associated with the risk of short-term and mid/long-term relapse after infliximab withdrawal in Crohn's patients: a proteomics-based study. Gut, ():(2020) [pubmed]
Keyword List
submitter keyword: Crohn's disease, biomarkers, relapse, selected reaction monitoring
Contact List
Edouard Louis
contact affiliationLaboratory of Translational Gastroenterology, GIGA-institute, University of Liège
contact emailedouard.Louis@uliege.be
lab head
Nicolas Pierre
contact affiliationLaboratory of Translational Gastroenterology, GIGA-institute, University of Liège, Liège, Belgium
contact emailnicolas.pierre@uliege.be
dataset submitter
Full Dataset Link List
Panorama Public dataset URI