PXD019434
PXD019434 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Discovery of biomarker candidates associated with the risk of short- and long-term relapse after infliximab withdrawal in Crohn’s patients: a proteomics-based study |
Description | Objective: A subset of Crohn’s disease (CD) patients experiences long-term remission after infliximab withdrawal. Biomarkers are needed to identify those patients.
Design: New biomarkers of relapse were searched in the baseline serum of CD patients stopping infliximab when they were under combined therapy (antimetabolite and infliximab) and stable clinical remission (STORI cohort, n=102). From shotgun proteomics experiment (discovery step), biomarker candidates were identified and further targeted by selected reaction monitoring (verification step). The dataset was stratified to search for markers of short- (<6 months) or long-term relapse (>6 months). The risk of relapse and the predicting capacity associated with biomarker candidates were evaluated using univariate Cox model and log-rank statistic, respectively. To test their complementary predicting capacity, biomarker candidates were systematically combined in pairs.
Results: Distinct biomarker candidates were associated with the risk (hazard ratio: HR) of short- (15 proteins, 2.9 |
HostingRepository | PanoramaPublic |
AnnounceDate | 2020-11-02 |
AnnouncementXML | Submission_2020-11-02_20:24:54.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Nicolas Pierre |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | Carbamidomethyl; Label:13C(6)15N(2) |
Instrument | Xevo TQ-S |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2020-05-27 21:54:54 | ID requested | |
⏵ 1 | 2020-11-02 20:24:55 | announced |
Publication List
Pierre N, Baiwir D, Huynh-Thu VA, Mazzucchelli G, Smargiasso N, De Pauw E, Bouhnik Y, Laharie D, Colombel JF, Meuwis MA, Louis E, Discovery of biomarker candidates associated with the risk of short-term and mid/long-term relapse after infliximab withdrawal in Crohn's patients: a proteomics-based study. Gut, ():(2020) [pubmed] |
Keyword List
submitter keyword: Crohn's disease, biomarkers, relapse, selected reaction monitoring |
Contact List
Edouard Louis | |
---|---|
contact affiliation | Laboratory of Translational Gastroenterology, GIGA-institute, University of Liège |
contact email | edouard.Louis@uliege.be |
lab head | |
Nicolas Pierre | |
contact affiliation | Laboratory of Translational Gastroenterology, GIGA-institute, University of Liège, Liège, Belgium |
contact email | nicolas.pierre@uliege.be |
dataset submitter |
Full Dataset Link List
Panorama Public dataset URI |