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PXD019423 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMS analysis of SARS-CoV2 proteins from patient samples
DescriptionWe developed a simple, MS-based method to specifically detect SARS-CoV-2 proteins from gargle solution samples of COVID-19 patients. Our protocol consists of an acetone precipitation and tryptic digestion of proteins contained within the gargle solution, followed by a targeted MS analysis. Our methodology identifies unique peptides originating from SARS-CoV-2 nucleoprotein. Building on these promising initial results, faster MS protocols can now be developed as routine diagnostic tools for COVID-19 patients. https://biorxiv.org/cgi/content/short/2020.04.18.047878v1
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterChristian Ihling
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListMet-loss; Deamidated; Met-loss+Acetyl; Oxidation; Acetyl; Carbamidomethyl; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-05-27 14:55:30ID requested
12020-06-25 01:25:44announced
Publication List
Ihling C, Tänzler D, Hagemann S, Kehlen A, Hüttelmaier S, Arlt C, Sinz A, Mass Spectrometric Identification of SARS-CoV-2 Proteins from Gargle Solution Samples of COVID-19 Patients. J Proteome Res, ():(2020) [pubmed]
Keyword List
ProteomeXchange project tag: Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project, Sars-CoV-2, Covid-19
submitter keyword: COVID-19, Mass spectrometry, Nucleoprotein, SARS-CoV-2
Contact List
Andrea Sinz
contact affiliationMartin-Luther University Halle-Wittenberg Institute of Pharmacy Department of Pharmaceutical Chemistry & Bioanalytics Charles Tanford Protein Center
contact emailandrea.sinz@pharmazie.uni-halle.de
lab head
Christian Ihling
contact affiliationMLU Halle, Inst. f. Pharmacy
contact emailchristian.ihling@pharmazie.uni-halle.de
dataset submitter
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PRIDE project URI
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