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PXD019327

PXD019327 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteome profiles of paired ovarian cancer ascites before and after chemotherapy
DescriptionOvarian cancer is characterized by transcoelomic metastasis into the peritoneal cavity. The peritoneal malignant ascites is enriched with ovarian cancer cells and a small amount of tumor-associated immune cells which create a unique microenvironment actively contributing to progression of the disease. However, it is remain unclear how cancer cells communicate to its local environment under the influence of chemotherapy. To address this issue, we performed LC-MS/MS analyses of ovarian cancer ascites from the same patients before and after chemotherapy. We found that neoadjuvant chemotherapy causes a significant changes in the composition of ascites, and these changes are similar in samples obtained from all patients (n=10). Functional annotation of upregulated proteins with the use of KEGG and GO databases revealed that malignant ascites after chemotherapy were enriched with the cluster of spliceosomal proteins. These splicing factors were linked to induction of epithelial-to-mesenchymal transition leading to a more aggressive phenotype of cancer cells.
HostingRepositoryPRIDE
AnnounceDate2024-05-29
AnnouncementXMLSubmission_2024-05-29_09:15:17.581.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD019327
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterGeorgij Arapidi
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListAmmonia-loss; Dehydrated; Oxidation; Acetyl; Carbamidomethyl; iodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-05-21 00:49:58ID requested
12024-05-29 09:15:17announced
Publication List
10.6019/PXD019327;
Keyword List
submitter keyword: Ovarian Cancer Ascites, Combinatorial Peptide Libraries, Therapy-induced Secretome
Contact List
Georgij Arapidi
contact affiliationFederal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Russia
contact emailarapidi@gmail.com
lab head
Georgij Arapidi
contact affiliationFederal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency
contact emailarapidi@gmail.com
dataset submitter
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Dataset FTP location
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PRIDE project URI
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