PXD019269

PXD019269 is an original dataset announced via ProteomeXchange.

Title	Phospho β-catenin Serine552 Predicts Recurrence of Non-Functioning Pituitary Tumors After Surgery
Description	NFPTs are tumors without a clinical evidence of hormone hypersecretion. Due to their lack of clinically detectable hormonal activity, they tend to present with mass effects. The molecular pathogenesis of NFPT is not well understood. Treatment of these non-functioning tumors is either surgery or radiotherapy. When recurrent, they are associated with severe morbidity. Characterization of phosphorylation status is critical to elucidate signaling pathways leading to tumorigenesis. Therefore, identifying phosphorylated proteins and their sites of phosphorylation will provide an important clue to the mechanism of NFPT pathogenesis, they can be used as predictor of aggressive behavior as well as activated kinases may be specifically targeted using small molecule inhibitors. Till date no study has undertaken global analysis of phosphoproteins in NFPTs. In this study, we designed an integrative approach involving identification of aberrant phosphorylation events in NFPTs using quantitative (Tandem mass tag-based) mass spectrometry based phosphoproteomic profiling followed by in-silico analysis and validation of candidate phosphoproteins in large cohort of NFPTs.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:05:36.072.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Akhilesh Pandey
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2020-05-18 16:58:49	ID requested
1	2022-10-13 08:44:59	announced
⏵ 2	2023-11-14 08:05:42	announced	2023-11-14: Updated project metadata.

Rai A, Yelamanchi SD, Radotra BD, Gupta SK, Mukherjee KK, Tripathi M, Chhabra R, Ahuja CK, Kumar N, Pandey A, Korbonits M, Dutta P, Gaston-Massuet C, -catenin at Serine552 correlates with invasion and recurrence of non-functioning pituitary neuroendocrine tumours. Acta Neuropathol Commun, 10(1):138(2022) [pubmed]

submitter keyword: phospho, Pituitary tumors, human, PTM, Mass spectrometry, NFPT,Non-Functioning Pituitary Tumors, phosphoproteomics, LC-MS/MS

Pinaki Dutta
contact affiliation	Department of Endocrinology PGIMER, Chandigarh India Dr. Akhilesh Pandey Department of Laboratory Medicine and Pathology Mayo Clinic Rochester, MN
contact email	pinaki_dutta@hotmail.com
lab head
Akhilesh Pandey
contact affiliation	Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905
contact email	pandey.akhilesh@mayo.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD019269

PRIDE project URI

• PRIDE
  1. PXD019269
     1. Label: PRIDE project
     2. Name: Phospho β-catenin Serine552 Predicts Recurrence of Non-Functioning Pituitary Tumors After Surgery