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PXD019251

PXD019251 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleInteractions of CDK19 with MED12 and cyclin-C assessed by chemical cross-linking mass spectrometry
DescriptionChemical cross-linking coupled to mass spectrometry was used to study binary and ternary complexes involving cyclin-dependent kinase 19 (CDK19), cyclin-C, and an N-terminal fragment of subunit 12 of the Mediator complex (MED12 1-100). Cross-linking was performed using disuccinimidyl suberate (DSS). These results were generated in the context of the study published as Klatt et al., A precisely positioned MED12 activation helix stimulates CDK8 kinase activity, Proc. Natl. Acad. Sci. USA 2020 (DOI: 10.1073/pnas.1917635117) with the associated data set PXD015394, but were not included in the article.
HostingRepositoryPRIDE
AnnounceDate2020-05-18
AnnouncementXMLSubmission_2020-05-18_04:45:55.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAlexander Leitner
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-05-18 02:24:37ID requested
12020-05-18 04:45:56announced
Publication List
Klatt F, Leitner A, Kim IV, Ho-Xuan H, Schneider EV, Langhammer F, Weinmann R, M, ü, ller MR, Huber R, Meister G, Kuhn CD, A precisely positioned MED12 activation helix stimulates CDK8 kinase activity. Proc Natl Acad Sci U S A, 117(6):2894-2905(2020) [pubmed]
Keyword List
submitter keyword: Chemical cross-linking
DSS
structural proteomics
mediator complex
kinase
Contact List
Claus-D. Kuhn
contact affiliationUniversity of Bayreuth, Universitätsstrasse 30, 95447 Bayreuth, Germany
contact emailClaus.Kuhn@uni-bayreuth.de
lab head
Alexander Leitner
contact affiliationETH Zurich, Institute of Molecular Systems Biology
contact emailleitner@imsb.biol.ethz.ch
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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