PXD019238

PXD019238 is an original dataset announced via ProteomeXchange.

Title	Identification of ribosome proteins bound to IRES in hypoxia
Description	Hypoxic conditions prompt internal ribosome entry site (IRES)-mediated translation of some of the hallmark cancer genes, such as VEGF. This translational switch is extremely vital for cell survival and tumor progression. Heterogeneity in ribosomes due to the diversity of ribosomal RNA (rRNA) and protein composition has been postulated to generate ‘specialized ribosomes’ that differentially regulate translation. A VEGF IRES sequence was used as bait to identify unique proteins bound at the IRES in breast cancer cells grown in hypoxia.
HostingRepository	PRIDE
AnnounceDate	2021-01-06
AnnouncementXML	Submission_2021-01-06_00:16:03.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD019238
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Brandon Metge
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Oxidation; Carbamidomethyl
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2020-05-17 16:32:54	ID requested
⏵ 1	2021-01-06 00:16:03	announced

Dataset with its publication pending

submitter keyword: hypoxia, ribosome, cancer, LC-MS, IRES

Rajeev Samant
contact affiliation	University of Alabama at Birmingham, Department of Pathology, Division MCP, O'Neal Comprehensive Cancer Center
contact email	rajeevsamant@uabmc.edu
lab head
Brandon Metge
contact affiliation	University of Alabama at Birmingham
contact email	brandonmetge@uabmc.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/01/PXD019238

PRIDE project URI

• PRIDE
  1. PXD019238
     1. Label: PRIDE project
     2. Name: Identification of ribosome proteins bound to IRES in hypoxia