PXD019222
PXD019222 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteome landscape of mouse primordial germ cells |
| Description | Primordial germ cells (PGCs) are precursors of both male and female gametes as fundamental materials for organism development. The transcriptome, methylome and chromatin accessibility profiles of PGCs in both mice and humans have been recently reported. However, little is known about the characteristics of PGCs at the protein levels, which directly exert cellular functions. Here, we construct landscapes of both proteome of mouse PGCs at E11.5, E13.5 and E16.5 days, the three critical developmental windows for PGCs’ sex differentiation, female meiosis initiation and male mitotic arrest. In each developmental stage of PGCs nearly 2000-3000 proteins are identified, among which specific functional pathways such as oxidative phosphorylation, DNA damage repair, and meiotic cell cycle are involved for different events during PGCs development. Thus, our work offers a valuable resource for the systematic investigations of PGC development at protein level. |
| HostingRepository | iProX |
| AnnounceDate | 2020-05-18 |
| AnnouncementXML | Submission_2020-09-28_21:07:02.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Pan Wang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2020-05-15 08:40:36 | ID requested | |
| 1 | 2020-05-18 19:54:04 | announced | |
| ⏵ 2 | 2020-09-28 21:07:02 | announced | 2020-09-29: Update publication information |
Publication List
| Wang P, Miao Y, Li XH, Zhang N, Wang Q, Yue W, Sun SC, Xiong B, Qiao J, Li M, Proteome landscape and spatial map of mouse primordial germ cells. Sci China Life Sci, 64(6):966-981(2021) [pubmed] |
Keyword List
| submitter keyword: Primordial germ cells, proteome, spatial map, sex differentiation, meiosis |
Contact List
| Mo Li | |
|---|---|
| contact affiliation | Peking University Third Hospital |
| contact email | limo@hsc.pku.edu.cn |
| lab head | |
| Pan Wang | |
| contact affiliation | Peking University Third Hospital |
| contact email | lenord2015@outlook.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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