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PXD019222

PXD019222 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteome landscape of mouse primordial germ cells
DescriptionPrimordial germ cells (PGCs) are precursors of both male and female gametes as fundamental materials for organism development. The transcriptome, methylome and chromatin accessibility profiles of PGCs in both mice and humans have been recently reported. However, little is known about the characteristics of PGCs at the protein levels, which directly exert cellular functions. Here, we construct landscapes of both proteome of mouse PGCs at E11.5, E13.5 and E16.5 days, the three critical developmental windows for PGCs’ sex differentiation, female meiosis initiation and male mitotic arrest. In each developmental stage of PGCs nearly 2000-3000 proteins are identified, among which specific functional pathways such as oxidative phosphorylation, DNA damage repair, and meiotic cell cycle are involved for different events during PGCs development. Thus, our work offers a valuable resource for the systematic investigations of PGC development at protein level.
HostingRepositoryiProX
AnnounceDate2020-05-18
AnnouncementXMLSubmission_2020-09-28_21:07:02.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterPan Wang
SpeciesList scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-05-15 08:40:36ID requested
12020-05-18 19:54:04announced
22020-09-28 21:07:02announced2020-09-29: Update publication information
Publication List
Wang P, Miao Y, Li XH, Zhang N, Wang Q, Yue W, Sun SC, Xiong B, Qiao J, Li M, Proteome landscape and spatial map of mouse primordial germ cells. Sci China Life Sci, 64(6):966-981(2021) [pubmed]
Keyword List
submitter keyword: Primordial germ cells, proteome, spatial map, sex differentiation, meiosis
Contact List
Mo Li
contact affiliationPeking University Third Hospital
contact emaillimo@hsc.pku.edu.cn
lab head
Pan Wang
contact affiliationPeking University Third Hospital
contact emaillenord2015@outlook.com
dataset submitter
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iProX dataset URI