PXD019207

PXD019207 is an original dataset announced via ProteomeXchange.

Title	Urine Large Extracellular Vesicle LC-MS/MS Data from a Chronic Kidney Disease Rat Model
Description	This study examined large renal tubule extracellular vesicles (LRT-EVs) isolated from urine of a 5/6 nephrectomy (5/6Nx) rat model that recapitulates many elements of human chronic kidney disease (CKD). Within weeks of 5/6Nx rats spontaneously exhibit proximal tubular damage including brush boarder shedding and the production of LRT-EVs. Analysis of the LRT-EV size and a lack of TUNEL staining in 5/6Nx rats, suggested LRT-EVs to be distinct from exosomes, microvesicles, and apoptotic bodies.
HostingRepository	PRIDE
AnnounceDate	2021-07-26
AnnouncementXML	Submission_2021-07-26_06:42:08.168.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD019207
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Brian Hoffmann
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	Oxidation; monohydroxylated residue; Carbamidomethyl; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2020-05-14 18:56:54	ID requested
⏵ 1	2021-07-26 06:42:08	announced

Adam RJ, Paterson MR, Wardecke L, Hoffmann BR, Kriegel AJ, Functionally Essential Tubular Proteins Are Lost to Urine-Excreted, Large Extracellular Vesicles during Chronic Renal Insufficiency. Kidney360, 1(10):1105-1115(2020) [pubmed]

submitter keyword: Kidney, Urine, Extracellular Vesicles, LC-MS/MS

Alison Kriegel, PhD
contact affiliation	Associate Professor Department of Physiology Medical College of Wisconsin
contact email	akriegel@mcw.edu
lab head
Brian Hoffmann
contact affiliation	Medical College of Wisconsin
contact email	bhoffmann@mcw.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/07/PXD019207

PRIDE project URI

• PRIDE
  1. PXD019207
     1. Label: PRIDE project
     2. Name: Urine Large Extracellular Vesicle LC-MS/MS Data from a Chronic Kidney Disease Rat Model