PXD019187

PXD019187 is an original dataset announced via ProteomeXchange.

Title	Equine gluteal muscle LC-MSMS: Warmblood
Description	Myofibrillar myopathy (MFM) in horses is a late onset disease that affects performance and athleticism. It is characterized by myofibrillar disarray and protein aggregation with no known cause. The objective of this study was to elucidate the molecular drivers of MFM in Warmblood (WB) horses by proteomic profiling (5 MFM WB, 4 non-MFM WB) of gluteal muscle. MFM horses used in this study had a chronic history of poor performance and exercise intolerance as well as accumulation of desmin aggregates in > 4 myofibers per muscle sample. The Equine Neuromuscular Diagnostic Laboratory database at Michigan State University was queried to identify WB horses with snap frozen gluteus medius biopsies available for analysis. Non-MFM control horses were defined as horses with no history of exercise intolerance and no evidence of desmin accumulation or other histopathology in muscle biopsies. Muscle biopsy samples were obtained at rest from horses that had not undertaken strenuous exercise in the preceding 48 hours.
HostingRepository	PRIDE
AnnounceDate	2021-09-09
AnnouncementXML	Submission_2021-09-09_00:36:27.277.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD019187
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Stephanie Valberg
SpeciesList	scientific name: Equus caballus (Horse); NCBI TaxID: 9796;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; Ammonia-loss; methionine oxidation with neutral loss of 64 Da; TMT6plex; Dehydrated; Oxidation; Acetyl; N-acetylated residue; Carbamidomethyl; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-05-14 04:44:32	ID requested
⏵ 1	2021-09-09 00:36:28	announced

Williams ZJ, Velez-Irizarry D, Gardner K, Valberg SJ, Integrated proteomic and transcriptomic profiling identifies aberrant gene and protein expression in the sarcomere, mitochondrial complex I, and the extracellular matrix in Warmblood horses with myofibrillar myopathy. BMC Genomics, 22(1):438(2021) [pubmed]

submitter keyword: horse, gluteal muscle, LC-MSMS

Stephanie Valberg
contact affiliation	Mary Anne McPhail Dressage Chair in Equine Sports Medicine Department Large Animal Clinical Sciences College of Veterinary Medicine Michigan State University
contact email	valbergs@msu.edu
lab head
Stephanie Valberg
contact affiliation	Michigan State University
contact email	valbergs@msu.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD019187

PRIDE project URI

• PRIDE
  1. PXD019187
     1. Label: PRIDE project
     2. Name: Equine gluteal muscle LC-MSMS: Warmblood