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PXD019169

PXD019169 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleGenome-wide pQTL analysis of protein expression regulatory networks in the human liver
DescriptionBackground: Previous expression quantitative trait loci (eQTL) studies have identified thousands of genetic variants to be associated with gene expression at the mRNA level in the human liver. However, protein expression often correlates poorly with mRNA levels. Thus, protein quantitative trait loci (pQTL) study is required to identify genetics variants that regulate protein expression in human livers. Results: We conducted a genome-wide pQTL study in 287 normal human liver samples and identified 900 local-pQTL variants and 4,026 distant-pQTL variants. We further discovered 53 genome hotspots of pQTL variants. Transcriptional region mapping analysis showed that 1,133 pQTL variants are in transcriptional regulatory regions. Genomic region enrichment analysis of the identified pQTL variants revealed 804 potential regulatory interactions among 595 regulators (e.g. non-coding RNAs) and 394 proteins. Moreover, pQTL variants and trait-variant integration analysis uncovered several novel mechanisms underlying the relationships between protein expression and liver diseases, such as alcohol dependence. Notably, over 2,000 of the identified pQTL variants have not been reported in previous eQTL studies, suggesting extensive involvement of genetic polymorphisms in post-transcriptional regulation of protein expression in human livers. Conclusions: We have partially established protein expression regulation networks in human livers and generated a wealth of pQTL data that could serve as a valuable resource for the scientific community.
HostingRepositoryPRIDE
AnnounceDate2020-07-21
AnnouncementXMLSubmission_2020-09-28_00:30:06.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterBing He
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentTripleTOF 5600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-05-13 17:41:17ID requested
12020-07-20 23:13:16announced
22020-09-28 00:30:07announced2020-09-28: Updated publication reference for PubMed record(s): 32778093.
Publication List
He B, Shi J, Wang X, Jiang H, Zhu HJ, Genome-wide pQTL analysis of protein expression regulatory networks in the human liver. BMC Biol, 18(1):97(2020) [pubmed]
Keyword List
submitter keyword: DIA,liver,HLS9
Contact List
Hao-Jie Zhu
contact affiliationDepartment of Clinical Pharmacy, University of Michigan
contact emailhjzhu@med.umich.edu
lab head
Bing He
contact affiliationUniversity of Michigan
contact emailhbing@umich.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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