PXD019129

PXD019129 is an original dataset announced via ProteomeXchange.

Title	Protein components of infective endocarditis vegetations and insights on their proteolysis using mass spectrometry-based N-terminomics
Description	Infective endocarditis results in the growth of a vegetative mass on native or bio prosthetic valves hindering function and increasing risk of thromboses. This study set out to determine the proteomic composition of these vegetations including the influence of different micro-organisms and the proteases known to be present. Our data has allowed us to describe for first time the influence different infectious organisms have on vegetation growth. Including the contribution of the immune response and circulatory proteins/cells make in composing a vegetation. Furthermore, we describe the protease activity and both known and novel cleavage sites in a plethora of targets. This data provides a deep insight into the homogeneity and heterogeneity of vegetation composition.
HostingRepository	PRIDE
AnnounceDate	2020-07-29
AnnouncementXML	Submission_2020-07-29_06:37:52.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD019129
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Daniel Martin
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Deamidated; Dimethyl; Oxidation; Acetyl; Carbamidomethyl; iodoacetamide derivatized residue; Gln->pyro-Glu
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2020-05-12 06:05:17	ID requested
⏵ 1	2020-07-29 06:37:53	announced

Martin DR, Witten JC, Tan CD, Rodriguez ER, Blackstone EH, Pettersson GB, Seifert DE, Willard BB, Apte SS, Proteomics identifies a convergent innate response to infective endocarditis and extensive proteolysis in vegetation components. JCI Insight, 5(14):(2020) [pubmed]

submitter keyword: Infective Endocarditis, N-terminomics, TAILS, Degradomics

Suneel Apte
contact affiliation	Cleveland Clinic, Lerner Research Institue, Biomedical Engineering, Cleveland, Ohio, USA
contact email	Aptes@ccf.org
lab head
Daniel Martin
contact affiliation	Cleveland Clinic
contact email	martin32@mail.usf.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/07/PXD019129

PRIDE project URI

• PRIDE
  1. PXD019129
     1. Label: PRIDE project
     2. Name: Protein components of infective endocarditis vegetations and insights on their proteolysis using mass spectrometry-based N-terminomics