PXD019107

PXD019107 is an original dataset announced via ProteomeXchange.

Title	IgE Effector Mechanisms, in Concert with Mast Cells, Contribute to Acquired Host Defense against Staphylococcus aureus
Description	Best known for their roles in allergic diseases, the physiologic function of immunoglobulin E (IgE) and mast cells (the so-called allergy module of immunity) has been enigmatic. Recent evidence shows that allergic reactions can help to protect against the toxicity of venoms. As bacteria are a potent alternative source of toxins, we assessed the potential role of the allergy module in antibacterial host defense. We observed that the immune response against S. aureus skin infection includes specific IgEs and substantially improves systemic host defense against secondary S. aureus infections in mice. This acquired protection depends on functional IgE effector mechanisms and mast cells. Our results reveal the powerful antibacterial potential of the allergy module and therefore a novel physiologic function of IgEs and mast cells.
HostingRepository	PRIDE
AnnounceDate	2020-10-14
AnnouncementXML	Submission_2020-10-14_05:23:26.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD019107
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Andre Mueller
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	Oxidation; Acetyl; Carbamidomethyl; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-05-11 22:56:21	ID requested
1	2020-09-10 00:27:42	announced
2	2020-10-14 00:09:11	announced	2020-10-14: Updated project metadata.
3	2020-10-14 00:10:38	announced	2020-10-14: Updated project metadata. 2020-10-14: Updated publication reference for PubMed record(s): 32910906.
⏵ 4	2020-10-14 05:23:28	announced	2020-10-14: Updated project metadata.

Starkl P, Watzenboeck ML, Popov LM, Zahalka S, Hladik A, Lakovits K, Radhouani M, Haschemi A, Marichal T, Reber LL, Gaudenzio N, Sibilano R, Stulik L, Fontaine F, Mueller AC, Amieva MR, Galli SJ, Knapp S, IgE Effector Mechanisms, in Concert with Mast Cells, Contribute to Acquired Host Defense against Staphylococcusaureus. Immunity, 53(4):793-804.e9(2020) [pubmed]

submitter keyword: human allergies, mast cells, IgE antibodies, host defense, bacterial infection

Sylvia Knapp
contact affiliation	Dept. of Medicine 1, Laboratory of Infection Biology, Medical University of Vienna
contact email	sylvia.knapp@meduniwien.ac.at
lab head
Andre Mueller
contact affiliation	Research Center for Molecular Medicine of the Austrian Academy of Sciences
contact email	amueller@cemm.oeaw.ac.at
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD019107
     1. Label: PRIDE project
     2. Name: IgE Effector Mechanisms, in Concert with Mast Cells, Contribute to Acquired Host Defense against Staphylococcus aureus