PXD019107 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | IgE Effector Mechanisms, in Concert with Mast Cells, Contribute to Acquired Host Defense against Staphylococcus aureus |
Description | Best known for their roles in allergic diseases, the physiologic function of immunoglobulin E (IgE) and mast cells (the so-called allergy module of immunity) has been enigmatic. Recent evidence shows that allergic reactions can help to protect against the toxicity of venoms. As bacteria are a potent alternative source of toxins, we assessed the potential role of the allergy module in antibacterial host defense. We observed that the immune response against S. aureus skin infection includes specific IgEs and substantially improves systemic host defense against secondary S. aureus infections in mice. This acquired protection depends on functional IgE effector mechanisms and mast cells. Our results reveal the powerful antibacterial potential of the allergy module and therefore a novel physiologic function of IgEs and mast cells. |
HostingRepository | PRIDE |
AnnounceDate | 2020-10-14 |
AnnouncementXML | Submission_2020-10-14_05:23:26.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD019107 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Andre Mueller |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | Oxidation; Acetyl; Carbamidomethyl; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-05-11 22:56:21 | ID requested | |
1 | 2020-09-10 00:27:42 | announced | |
2 | 2020-10-14 00:09:11 | announced | 2020-10-14: Updated project metadata. |
3 | 2020-10-14 00:10:38 | announced | 2020-10-14: Updated project metadata.
2020-10-14: Updated publication reference for PubMed record(s): 32910906. |
⏵ 4 | 2020-10-14 05:23:28 | announced | 2020-10-14: Updated project metadata. |
Publication List
Starkl P, Watzenboeck ML, Popov LM, Zahalka S, Hladik A, Lakovits K, Radhouani M, Haschemi A, Marichal T, Reber LL, Gaudenzio N, Sibilano R, Stulik L, Fontaine F, Mueller AC, Amieva MR, Galli SJ, Knapp S, IgE Effector Mechanisms, in Concert with Mast Cells, Contribute to Acquired Host Defense against Staphylococcusaureus. Immunity, 53(4):793-804.e9(2020) [pubmed] |
Keyword List
submitter keyword: human allergies, mast cells, IgE antibodies, host defense, bacterial infection |
Contact List
Sylvia Knapp |
contact affiliation | Dept. of Medicine 1, Laboratory of Infection Biology, Medical University of Vienna |
contact email | sylvia.knapp@meduniwien.ac.at |
lab head | |
Andre Mueller |
contact affiliation | Research Center for Molecular Medicine of the Austrian Academy of Sciences |
contact email | amueller@cemm.oeaw.ac.at |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD019107
- Label: PRIDE project
- Name: IgE Effector Mechanisms, in Concert with Mast Cells, Contribute to Acquired Host Defense against Staphylococcus aureus