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PXD019107

PXD019107 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIgE Effector Mechanisms, in Concert with Mast Cells, Contribute to Acquired Host Defense against Staphylococcus aureus
DescriptionBest known for their roles in allergic diseases, the physiologic function of immunoglobulin E (IgE) and mast cells (the so-called allergy module of immunity) has been enigmatic. Recent evidence shows that allergic reactions can help to protect against the toxicity of venoms. As bacteria are a potent alternative source of toxins, we assessed the potential role of the allergy module in antibacterial host defense. We observed that the immune response against S. aureus skin infection includes specific IgEs and substantially improves systemic host defense against secondary S. aureus infections in mice. This acquired protection depends on functional IgE effector mechanisms and mast cells. Our results reveal the powerful antibacterial potential of the allergy module and therefore a novel physiologic function of IgEs and mast cells.
HostingRepositoryPRIDE
AnnounceDate2020-10-14
AnnouncementXMLSubmission_2020-10-14_05:23:26.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD019107
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterAndre Mueller
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListOxidation; Acetyl; Carbamidomethyl; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-05-11 22:56:21ID requested
12020-09-10 00:27:42announced
22020-10-14 00:09:11announced2020-10-14: Updated project metadata.
32020-10-14 00:10:38announced2020-10-14: Updated project metadata.
2020-10-14: Updated publication reference for PubMed record(s): 32910906.
42020-10-14 05:23:28announced2020-10-14: Updated project metadata.
Publication List
Starkl P, Watzenboeck ML, Popov LM, Zahalka S, Hladik A, Lakovits K, Radhouani M, Haschemi A, Marichal T, Reber LL, Gaudenzio N, Sibilano R, Stulik L, Fontaine F, Mueller AC, Amieva MR, Galli SJ, Knapp S, IgE Effector Mechanisms, in Concert with Mast Cells, Contribute to Acquired Host Defense against Staphylococcusaureus. Immunity, 53(4):793-804.e9(2020) [pubmed]
Keyword List
submitter keyword: human allergies, mast cells, IgE antibodies, host defense, bacterial infection
Contact List
Sylvia Knapp
contact affiliationDept. of Medicine 1, Laboratory of Infection Biology, Medical University of Vienna
contact emailsylvia.knapp@meduniwien.ac.at
lab head
Andre Mueller
contact affiliationResearch Center for Molecular Medicine of the Austrian Academy of Sciences
contact emailamueller@cemm.oeaw.ac.at
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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