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PXD019104

PXD019104 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHistone post-translational modifications of Trypanosoma cruzi: a high-confidence comprehensive map
DescriptionIn humans and other eukaryotes, histone post-translational modifications (hPTMs) play an essential role in the epigenetic control of gene expression. In trypanosomatid parasites, conversely, gene regulation occurs mainly at the post-transcriptional level. However, our group has recently shown that hPTMs are abundant and varied in Trypanosoma cruzi, the etiological agent of Chagas Disease, signaling for possible conserved epigenetic functions. Here, we provide a high-confidence comprehensive map of hPTMs, distributed in all canonical, variant and linker histones of T. cruzi. Our updated landscape expands the number of known T. cruzi hPTMs by almost 2-fold, representing the largest dataset of hPTMs available to any trypanosomatid to date, and can be used as a basis for functional studies on the dynamic regulation of chromatin by epigenetic mechanisms and the selection of candidates for the development of epigenetic drugs in trypanosomatids.
HostingRepositoryPRIDE
AnnounceDate2021-04-07
AnnouncementXMLSubmission_2021-04-07_00:25:21.851.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD019104
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterLyris de Godoy
SpeciesList scientific name: Trypanosoma cruzi; NCBI TaxID: 5693;
ModificationListmonomethylated residue; Phospho; Deamidated; trimethylated residue; phosphorylated residue; Oxidation; Acetyl; monohydroxylated residue; acetylated residue; dimethylated residue
InstrumentLTQ Orbitrap XL ETD
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-05-11 17:26:03ID requested
12021-03-04 14:21:00announced
22021-04-07 00:25:22announced2021-04-07: Updated project metadata.
Publication List
de Almeida RF, Fernandes M, de Godoy LMF, An updated map of Trypanosoma cruzi histone post-translational modifications. Sci Data, 8(1):93(2021) [pubmed]
Keyword List
submitter keyword: post-translational modifications, trypanosoma cruzi,histone, trypanosomatids
Contact List
Lyris Martins Franco de Godoy
contact affiliationInstituto Carlos Chagas, FIOCRUZ Parana
contact emaillyris.godoy@fiocruz.br
lab head
Lyris de Godoy
contact affiliationInstituto Carlos Chagas - Fiocruz Parana
contact emaillyris.godoy@fiocruz.br
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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