PXD019104

PXD019104 is an original dataset announced via ProteomeXchange.

Title	Histone post-translational modifications of Trypanosoma cruzi: a high-confidence comprehensive map
Description	In humans and other eukaryotes, histone post-translational modifications (hPTMs) play an essential role in the epigenetic control of gene expression. In trypanosomatid parasites, conversely, gene regulation occurs mainly at the post-transcriptional level. However, our group has recently shown that hPTMs are abundant and varied in Trypanosoma cruzi, the etiological agent of Chagas Disease, signaling for possible conserved epigenetic functions. Here, we provide a high-confidence comprehensive map of hPTMs, distributed in all canonical, variant and linker histones of T. cruzi. Our updated landscape expands the number of known T. cruzi hPTMs by almost 2-fold, representing the largest dataset of hPTMs available to any trypanosomatid to date, and can be used as a basis for functional studies on the dynamic regulation of chromatin by epigenetic mechanisms and the selection of candidates for the development of epigenetic drugs in trypanosomatids.
HostingRepository	PRIDE
AnnounceDate	2021-04-07
AnnouncementXML	Submission_2021-04-07_00:25:21.851.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD019104
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Lyris de Godoy
SpeciesList	scientific name: Trypanosoma cruzi; NCBI TaxID: 5693;
ModificationList	monomethylated residue; Phospho; Deamidated; trimethylated residue; phosphorylated residue; Oxidation; Acetyl; monohydroxylated residue; acetylated residue; dimethylated residue
Instrument	LTQ Orbitrap XL ETD

Revision	Datetime	Status	ChangeLog Entry
0	2020-05-11 17:26:03	ID requested
1	2021-03-04 14:21:00	announced
⏵ 2	2021-04-07 00:25:22	announced	2021-04-07: Updated project metadata.

de Almeida RF, Fernandes M, de Godoy LMF, An updated map of Trypanosoma cruzi histone post-translational modifications. Sci Data, 8(1):93(2021) [pubmed]

submitter keyword: post-translational modifications, trypanosoma cruzi,histone, trypanosomatids

Lyris Martins Franco de Godoy
contact affiliation	Instituto Carlos Chagas, FIOCRUZ Parana
contact email	lyris.godoy@fiocruz.br
lab head
Lyris de Godoy
contact affiliation	Instituto Carlos Chagas - Fiocruz Parana
contact email	lyris.godoy@fiocruz.br
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/01/PXD019104

PRIDE project URI

• PRIDE
  1. PXD019104
     1. Label: PRIDE project
     2. Name: Histone post-translational modifications of Trypanosoma cruzi: a high-confidence comprehensive map