PXD019104 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Histone post-translational modifications of Trypanosoma cruzi: a high-confidence comprehensive map |
Description | In humans and other eukaryotes, histone post-translational modifications (hPTMs) play an essential role in the epigenetic control of gene expression. In trypanosomatid parasites, conversely, gene regulation occurs mainly at the post-transcriptional level. However, our group has recently shown that hPTMs are abundant and varied in Trypanosoma cruzi, the etiological agent of Chagas Disease, signaling for possible conserved epigenetic functions. Here, we provide a high-confidence comprehensive map of hPTMs, distributed in all canonical, variant and linker histones of T. cruzi. Our updated landscape expands the number of known T. cruzi hPTMs by almost 2-fold, representing the largest dataset of hPTMs available to any trypanosomatid to date, and can be used as a basis for functional studies on the dynamic regulation of chromatin by epigenetic mechanisms and the selection of candidates for the development of epigenetic drugs in trypanosomatids. |
HostingRepository | PRIDE |
AnnounceDate | 2021-04-07 |
AnnouncementXML | Submission_2021-04-07_00:25:21.851.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD019104 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Lyris de Godoy |
SpeciesList | scientific name: Trypanosoma cruzi; NCBI TaxID: 5693; |
ModificationList | monomethylated residue; Phospho; Deamidated; trimethylated residue; phosphorylated residue; Oxidation; Acetyl; monohydroxylated residue; acetylated residue; dimethylated residue |
Instrument | LTQ Orbitrap XL ETD |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-05-11 17:26:03 | ID requested | |
1 | 2021-03-04 14:21:00 | announced | |
⏵ 2 | 2021-04-07 00:25:22 | announced | 2021-04-07: Updated project metadata. |
Publication List
de Almeida RF, Fernandes M, de Godoy LMF, An updated map of Trypanosoma cruzi histone post-translational modifications. Sci Data, 8(1):93(2021) [pubmed] |
Keyword List
submitter keyword: post-translational modifications, trypanosoma cruzi,histone, trypanosomatids |
Contact List
Lyris Martins Franco de Godoy |
contact affiliation | Instituto Carlos Chagas, FIOCRUZ Parana |
contact email | lyris.godoy@fiocruz.br |
lab head | |
Lyris de Godoy |
contact affiliation | Instituto Carlos Chagas - Fiocruz Parana |
contact email | lyris.godoy@fiocruz.br |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD019104
- Label: PRIDE project
- Name: Histone post-translational modifications of Trypanosoma cruzi: a high-confidence comprehensive map