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PXD019087

PXD019087 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing.
DescriptionThe PIWI protein MIWI2 and its associated PIWI-interacting RNAs (piRNAs) instruct DNA methylation of young active transposable elements (TEs) in the male germline. Here we show that MIWI2 associates with TEX15 in foetal gonocytes. TEX15 is predominantly a nuclear protein that is not required for piRNA biogenesis but is essential for piRNA-directed TE de novo methylation and silencing. In summary, TEX15 is an essential executor of mammalian piRNA-directed DNA methylation.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:07:25.160.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterTania Auchynnikava
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-05-11 07:51:27ID requested
12020-06-17 22:17:38announced
22020-08-11 04:43:54announced2020-08-11: Updated publication reference for PubMed record(s): 32719317.
32024-10-22 05:07:26announced2024-10-22: Updated project metadata.
Publication List
10.1038/s41467-020-17372-5;
Sch, ö, pp T, Zoch A, Berrens RV, Auchynnikava T, Kabayama Y, Vasiliauskait, ė L, Rappsilber J, Allshire RC, O'Carroll D, TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing. Nat Commun, 11(1):3739(2020) [pubmed]
Keyword List
submitter keyword: Mouse transposon silencing
Contact List
Donal O'Carroll
contact affiliation1. MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, UK. 2. Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, EH9 3BF, UK.
contact emaildonal.ocarroll@ed.ac.uk
lab head
Tania Auchynnikava
contact affiliationWCB, The University of Edinburgh
contact emailT.Auchynnikava@ed.ac.uk
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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