PXD019052

PXD019052 is an original dataset announced via ProteomeXchange.

Title	The Matrisome Reveals the Characterization of Skin Keloid Microenvironment
Description	Keloids are fibroproliferative dermal tumors of unknown origin that are characterized by the overabundant accumulation of extracellular matrix (ECM) components. The mechanism of keloid formation has remained unclear because of a poor understanding of its molecular basis. In this study, the dermal ECM components of keloids were identified, and the pathological mechanism of keloid formation was characterized using large-scale, quantitative proteomic analyses of decellularized keloid biomatrix scaffolds. We identified a total of 267 dermal core ECM and ECM-associated proteins that were differentially expressed between patients with keloids and healthy controls. Skin mechanical properties, key pathways, and biological processes including protease activity, wound healing, and adhesion were disordered in keloids. The integrated network analysis of the upregulated ECM proteins revealed the involvement of estrogen signaling pathways in keloid formation. Our findings may improve the scientific basis of keloid treatment and provide new ideas for the establishment of keloid models.
HostingRepository	iProX
AnnounceDate	2020-05-08
AnnouncementXML	Submission_2023-08-13_20:34:22.868.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jie Ma
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-05-07 22:53:27	ID requested
⏵ 1	2023-08-13 20:34:23	announced

Zhang S, Liu B, Wang W, Lv L, Gao D, Chai M, Li M, Wu Z, Zhu Y, Ma J, Leng L, The "Matrisome" reveals the characterization of skin keloid microenvironment. FASEB J, 35(4):e21237(2021) [pubmed]

submitter keyword: skin, keloid, extracellular matrix, biomatrix scaffold, matrisome

Yunping Zhu
contact affiliation	National Center for Protein Sciences (Beijing), Beijing Institute of Life Omics.
contact email	zhuyunping@gmail.com
lab head
Jie Ma
contact affiliation	National Center for Protein Sciences (Beijing), Beijing Institute of Life Omics.
contact email	majie729@163.com
dataset submitter

iProX dataset URI