PXD019033

PXD019033 is an original dataset announced via ProteomeXchange.

Title	First proteomic analysis of lysine acetylation on extensive functions in Solenopsis invicta Buren
Description	Lysine acetylation (Kac) plays a critical role in the regulation of a great deal of important cellular processes. However, little is known about Kac in Solenopsis invicta, which is one of the 100 most dangerous invasive species in the world. Lysine acetylome in S. invicta was evaluated for the first time in this study. Altogether, 2387 Kac sites were tested in 992 proteins. The prediction of subcellular localization indicated that most identified proteins were located in cytoplasm, mitochondria and nucleus. The enriched Kac site motifs included Kac H, Kac Y, Kac G, Kac F, Kac T, and Kac W. H, Y, F, and W were of frequent occurrence at the +1 position, whereas G, Y and T were of frequent occurrence at the –1 position. Based on cellular component, acetylated proteins were enriched in cytoplasmic part, mitochondrial matrix, and cytosolic ribosome. Furthermore, 25 pathways were detected to be significantly enriched. Interestingly, arginine and proline metabolism as well asphagosome, which were related to immunity, contained several Kac proteins. Acetylation or deacetylation of the proline and phagosome proteins may adjust the protein function, which may be why S. invicta was highly immune. As for interaction network investigation, diverse interactions were adjusted by Kac. Our study of lysine acetylome supplies abundant information for function analysis of reversible Kac in the growth and development of S. invicta and other Hymenoptera insects. Confirming the functions of Kac target proteins may be useful to design specific and effective drugs to prevent and control this dangerous invasive species.
HostingRepository	PRIDE
AnnounceDate	2020-12-02
AnnouncementXML	Submission_2020-12-02_04:03:01.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jingwen Ye
SpeciesList	scientific name: Solenopsis invicta; NCBI TaxID: 13686;
ModificationList	acetylated residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2020-05-07 01:20:24	ID requested
⏵ 1	2020-12-02 04:03:01	announced

Dataset with its publication pending

submitter keyword: lysine acetylation;Solenopsis invicta;subcellular localization;enrichment

Jingwen ye
contact affiliation	Guangdong Institute of Applied Biological Resources, Guangdong Academy of Science
contact email	jingwenye@163.com
lab head
Jingwen Ye
contact affiliation	Guangdong Institute of Applied Biological Resources, Guangdong Academy of Science
contact email	jingwenye@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/12/PXD019033

PRIDE project URI

• PRIDE
  1. PXD019033
     1. Label: PRIDE project
     2. Name: First proteomic analysis of lysine acetylation on extensive functions in Solenopsis invicta Buren