PXD018999

PXD018999 is an original dataset announced via ProteomeXchange.

Title	A dichotomous response to chronic fetal hypoxia preprograms aging already during kidney development
Description	Hypoxia-induced intrauterine growth restriction increases the risk for chronic diseases in adults, affecting more than 140 million high altitude residents worldwide. Still, not much is known about the fetal mechanisms that prone these individuals to disease. Using bottom-up proteomics and the kidney as a readout, we delineated a dichotomous response to chronic hypoxic stress, comprising mechanisms that promote survival, but also induce premature senescence. Combined outcome is the manifestation of a predetermined aging phenotype already during fetal development. This aging phenotype is associated with a characteristic biomarker profile in tissue and blood serum samples, exploitable for targeting and monitoring disease.
HostingRepository	PRIDE
AnnounceDate	2024-10-08
AnnouncementXML	Submission_2024-10-08_11:11:21.630.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD018999
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Christopher Gerner
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	Oxidation; Acetyl; Carbamidomethyl; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-05-05 07:14:48	ID requested
⏵ 1	2024-10-08 11:11:22	announced

10.6019/PXD018999;

submitter keyword: mass spectrometry, hypoxia, kidney development, tissue proteomics,aging, high performance liquid chromatography

Christopher Gerner
contact affiliation	Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna
contact email	christopher.gerner@univie.ac.at
lab head
Christopher Gerner
contact affiliation	University of Vienna
contact email	christopher.gerner@univie.ac.at
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD018999
     1. Label: PRIDE project
     2. Name: A dichotomous response to chronic fetal hypoxia preprograms aging already during kidney development