PXD018999 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | A dichotomous response to chronic fetal hypoxia preprograms aging already during kidney development |
Description | Hypoxia-induced intrauterine growth restriction increases the risk for chronic diseases in adults, affecting more than 140 million high altitude residents worldwide. Still, not much is known about the fetal mechanisms that prone these individuals to disease. Using bottom-up proteomics and the kidney as a readout, we delineated a dichotomous response to chronic hypoxic stress, comprising mechanisms that promote survival, but also induce premature senescence. Combined outcome is the manifestation of a predetermined aging phenotype already during fetal development. This aging phenotype is associated with a characteristic biomarker profile in tissue and blood serum samples, exploitable for targeting and monitoring disease. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-08 |
AnnouncementXML | Submission_2024-10-08_11:11:21.630.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD018999 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Christopher Gerner |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | Oxidation; Acetyl; Carbamidomethyl; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-05-05 07:14:48 | ID requested | |
⏵ 1 | 2024-10-08 11:11:22 | announced | |
Publication List
Keyword List
submitter keyword: mass spectrometry, hypoxia, kidney development, tissue proteomics,aging, high performance liquid chromatography |
Contact List
Christopher Gerner |
contact affiliation | Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna |
contact email | christopher.gerner@univie.ac.at |
lab head | |
Christopher Gerner |
contact affiliation | University of Vienna |
contact email | christopher.gerner@univie.ac.at |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD018999
- Label: PRIDE project
- Name: A dichotomous response to chronic fetal hypoxia preprograms aging already during kidney development