PXD018961

PXD018961 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	SHMT2 controls Burkitt lymphoma cell survival by maintaining an oncogenic TCF3 transcriptional program
Description	In this study, the human Burkitt’s Lymphoma cell line BL60 has been analysed via proteomic and phosphoproteomic analysis for effect of a knock down of the serine hydroxymethyltransferase 2 (shSHMT2) compared to a control construct (shGL2). Concerning the phosphoproteome, these results have been compared to an analysis of a knock down of CD79a (shCD79a) in these cells.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:25:28.322.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Anne Wilke
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2020-05-04 01:25:44	ID requested
1	2023-03-10 19:05:08	announced
⏵ 2	2023-11-14 08:25:29	announced	2023-11-14: Updated project metadata.

Publication List

Wilke AC, Doebele C, Zindel A, Lee KS, Rieke SA, Ceribelli M, Comoglio F, Phelan JD, Wang JQ, Pikman Y, Jahn D, H, ä, upl B, Schneider C, Scheich S, Tosto FA, Bohnenberger H, Stauder P, Schn, ü, tgen F, Slabicki M, Coulibaly ZA, Wolf S, Bojarczuk K, Chapuy B, Brandts CH, Stroebel P, Lewis CA, Engelke M, Xu X, Kim H, Dang TH, Schmitz R, Hodson DJ, Stegmaier K, Urlaub H, Serve H, Schmitt CA, Kreuz F, Knittel G, Rabinowitz JD, Reinhardt HC, Vander Heiden MG, Thomas C, Staudt LM, Zenz T, Oellerich T, SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma. Blood, 139(4):538-553(2022) [pubmed]

Wilke AC, Doebele C, Zindel A, Lee KS, Rieke SA, Ceribelli M, Comoglio F, Phelan JD, Wang JQ, Pikman Y, Jahn D, H, ä, upl B, Schneider C, Scheich S, Tosto FA, Bohnenberger H, Stauder P, Schn, ü, tgen F, Slabicki M, Coulibaly ZA, Wolf S, Bojarczuk K, Chapuy B, Brandts CH, Stroebel P, Lewis CA, Engelke M, Xu X, Kim H, Dang TH, Schmitz R, Hodson DJ, Stegmaier K, Urlaub H, Serve H, Schmitt CA, Kreuz F, Knittel G, Rabinowitz JD, Reinhardt HC, Vander Heiden MG, Thomas C, Staudt LM, Zenz T, Oellerich T, SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma. Blood, 139(4):538-553(2022) [pubmed]

Keyword List

submitter keyword: B cell receptor, One carbon metabolism,Burkitt’s Lymphoma

submitter keyword: B cell receptor, One carbon metabolism,Burkitt’s Lymphoma

Contact List

Thomas Oellerich
contact affiliation	Department of Medicine II Haematology/Oncology Goethe University Theodor-Stern-Kai 7 60590 Frankfurt Germany
contact email	Thomas.oellerich@kgu.de
lab head
Anne Wilke
contact affiliation	University Hospital of Frankfurt, Medical Clinic II, Dept. of Hematology/Oncology
contact email	anne.wilke@kgu.de
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD018961
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD018961

PRIDE project URI

Repository Record List

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