<<< Full experiment listing

PXD018937

PXD018937 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleRapid and direct control of target protein levels with VHL-recruiting dTAG molecules
DescriptionChemical biology strategies for directly perturbing protein homeostasis including the degradation tag (dTAG) system provide temporal advantages over genetic approaches and improved selectivity over small molecule inhibitors. We describe dTAGV-1, an exclusively selective VHL-recruiting dTAG molecule, to rapidly degrade FKBP12F36V-tagged proteins. dTAGV-1 overcomes a limitation of previously reported CRBN-recruiting dTAG molecules to degrade recalcitrant oncogenes, supports combination degrader studies and facilitates investigations of protein function in cells and mice
HostingRepositoryPRIDE
AnnounceDate2020-09-23
AnnouncementXMLSubmission_2020-09-23_07:01:54.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterBehnam Nabet
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-04-30 15:39:29ID requested
12020-09-23 07:01:55announced
Publication List
Nabet B, Ferguson FM, Seong BKA, Kuljanin M, Leggett AL, Mohardt ML, Robichaud A, Conway AS, Buckley DL, Mancias JD, Bradner JE, Stegmaier K, Gray NS, Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules. Nat Commun, 11(1):4687(2020) [pubmed]
Keyword List
submitter keyword: PROTAC, dTAG, proteomics, degraders
Contact List
Nathanael Gray
contact affiliationDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School,
contact emailnathanael_gray@dfci.harvard.edu
lab head
Behnam Nabet
contact affiliationDana-Farber Cancer Institute
contact emailbehnam_nabet@dfci.harvard.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/09/PXD018937
PRIDE project URI
Repository Record List
[ + ]