PXD018937 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules |
Description | Chemical biology strategies for directly perturbing protein homeostasis including the degradation tag (dTAG) system provide temporal advantages over genetic approaches and improved selectivity over small molecule inhibitors. We describe dTAGV-1, an exclusively selective VHL-recruiting dTAG molecule, to rapidly degrade FKBP12F36V-tagged proteins. dTAGV-1 overcomes a limitation of previously reported CRBN-recruiting dTAG molecules to degrade recalcitrant oncogenes, supports combination degrader studies and facilitates investigations of protein function in cells and mice |
HostingRepository | PRIDE |
AnnounceDate | 2020-09-23 |
AnnouncementXML | Submission_2020-09-23_07:01:54.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Behnam Nabet |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-04-30 15:39:29 | ID requested | |
⏵ 1 | 2020-09-23 07:01:55 | announced | |
Publication List
Nabet B, Ferguson FM, Seong BKA, Kuljanin M, Leggett AL, Mohardt ML, Robichaud A, Conway AS, Buckley DL, Mancias JD, Bradner JE, Stegmaier K, Gray NS, Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules. Nat Commun, 11(1):4687(2020) [pubmed] |
Keyword List
submitter keyword: PROTAC, dTAG, proteomics, degraders |
Contact List
Nathanael Gray |
contact affiliation | Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, |
contact email | nathanael_gray@dfci.harvard.edu |
lab head | |
Behnam Nabet |
contact affiliation | Dana-Farber Cancer Institute |
contact email | behnam_nabet@dfci.harvard.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/09/PXD018937 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD018937
- Label: PRIDE project
- Name: Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules