PXD018917

PXD018917 is an original dataset announced via ProteomeXchange.

Title	A Quantitative Yeast Aging Proteomics Analysis Reveals Novel Aging Regulators
Description	Extending lifespan from yeast to mammals, calorie restriction (CR) is the most conserved longevity intervention. Numerous conserved pathways regulating aging and mediating CR have been identified; however, the overall proteomic changes during these conditions remain largely unexplored. We compared proteomes between young and replicatively aged yeast cells under normal and CR conditions using SILAC quantitative proteomics and discovered distinct signatures in the aging proteome. We found remarkable similarities between aged and CR cells, including induction of stress response pathways, providing evidence that CR pathways are engaged in aged cells. These observations also uncovered aberrant changes in mitochondria membrane proteins as well as a proteolytic cellular state in old cells. These proteomics analyses also help identify potential genes and pathways that have causal effects on longevity.
HostingRepository	PRIDE
AnnounceDate	2022-02-15
AnnouncementXML	Submission_2022-02-15_11:14:11.031.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ruofan Yu
SpeciesList	scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2020-04-29 17:32:03	ID requested
⏵ 1	2022-02-15 11:14:11	announced

Sun Y, Yu R, Guo HB, Qin H, Dang W, A quantitative yeast aging proteomics analysis reveals novel aging regulators. Geroscience, 43(5):2573-2593(2021) [pubmed]

submitter keyword: Yeast, Proteome, Aging, Replicative aging, Caloric restriction

Weiwei Dang
contact affiliation	Huffington Center on Aging, Baylor College of Medicine, Houston, TX, United States
contact email	weiwei.dang@bcm.edu
lab head
Ruofan Yu
contact affiliation	Baylor College of Medicine
contact email	ruofanyu90@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD018917

PRIDE project URI

• PRIDE
  1. PXD018917
     1. Label: PRIDE project
     2. Name: A Quantitative Yeast Aging Proteomics Analysis Reveals Novel Aging Regulators