PXD018885

PXD018885 is an original dataset announced via ProteomeXchange.

Title	Red-fleshed apples rich in anthocyanins and white-fleshed apples poor in anthocyanins modulate aorta and heart proteome in hypercholesterolemic rats. The AppleCOR study
Description	New mechanisms-of-action of anthocyanins (ACNs) provided by a red-fleshed apple compared with a white-fleshed apple ACN-poor, and with an ACN-rich extract on the proteome profile of aorta and heart as cardiovascular key tissues were determined. Hypercholesterolemic Wistar rats were separated into the corresponding groups to analyze the proteomic profile of the aorta and heart tissues using nano-liquid chromatography coupled to mass-spectrometry. Red-fleshed apple downregulated CRP, C1QB and CFP related-inflammation. White-fleshed apple reduced C1QB, CFB, CFD, C3, and C9 related to the complement system, reduced MB and CP related to iron metabolism, and increased ME1, PKM, and PC related to energy homeostasis. ACN-rich extract increased FMOD, TAGLN, and CAP1 related to cellular structure and decreased PRKACA, IQGAP1, and HSP90AB1 related to cellular signaling. Red-fleshed apple rich in ACNs suggested an anti-inflammatory effect while white-fleshed apple reduced the complement system protein-related. An apple matrix effect reduced inflammatory proteins regardless their ACN content.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:36:51.128.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Pol Herrero
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2020-04-28 22:34:43	ID requested
1	2022-05-25 05:05:31	announced
⏵ 2	2024-10-22 05:36:58	announced	2024-10-22: Updated project metadata.

10.3390/nu14051047;

Catal, á, n Ú, Pedret A, Yuste S, Rubi, ó L, Pi, ñ, ol C, Sandoval-Ram, í, rez BA, Companys J, Foguet E, Herrero P, Canela N, Motilva MJ, Sol, à R, Red-Fleshed Apples Rich in Anthocyanins and White-Fleshed Apples Modulate the Aorta and Heart Proteome in Hypercholesterolaemic Rats: The AppleCOR Study. Nutrients, 14(5):(2022) [pubmed]

submitter keyword: rat tissues, proteomics,anthocyanins, phenolic compounds, apple

Nuria Canela
contact affiliation	Eurecat, Centre Tecnològic de Catalunya. Centre for Omic Sciences (COS), Joint Unit Universitat Rovira i Virgili-EURECAT. Reus, Spain
contact email	nuria.canela@eurecat.org
lab head
Pol Herrero
contact affiliation	Centre for Omic Sciences (COS) - Universitat Rovira i Virgili (URV)-EURECAT
contact email	pol.herrero@urv.cat
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD018885

PRIDE project URI

• PRIDE
  1. PXD018885
     1. Label: PRIDE project
     2. Name: Red-fleshed apples rich in anthocyanins and white-fleshed apples poor in anthocyanins modulate aorta and heart proteome in hypercholesterolemic rats. The AppleCOR study