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PXD018827

PXD018827 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic investigation of treatment with medicinal mushroom supplement Agarikon.1® in advanced colorectal cancer animal model
DescriptionColorectal cancer (CRC) is the third most frequent cancer type in both males and females, with about 35% of patients being diagnosed in stage IV metastatic disease. Despite advancements in treatment, life expectancy in patients with metastatic disease is low. Due to frequent drug resistance during conventional and targeted cancer treatments, the development and testing of multi-target therapies is an important objective. Medicinal mushrooms specific compound isolates as well as complex extract mixtures have been studied in depth, and many mushroom species have been proven to be non-toxic multi-target inhibitors of specific oncogenic pathways, as well as potent immunomodulators. In this study, we have performed a tandem mass tags qualitative and quantitative proteomic analyses of CT26.WT colon cancer tumor tissues from Balb/c mice treated with proprietary medicinal mushroom extract Agarikon.1®, with or without 5-fluorouracil.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:14:18.177.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAnita Horvatic
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive Plus
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-04-27 03:51:31ID requested
12020-10-27 03:22:21announced
22024-10-22 05:14:19announced2024-10-22: Updated project metadata.
Publication List
Jakopovic B, Horvati, ć A, Klobu, č, ar M, Gelemanovi, ć A, Grb, č, i, ć P, Or, š, oli, ć N, Jakopovich I, Kraljevi, ć, Paveli, ć S, Treatment With Medicinal Mushroom Extract Mixture Inhibits Translation and Reprograms Metabolism in Advanced Colorectal Cancer Animal Model as Evidenced by Tandem Mass Tags Proteomics Analysis. Front Pharmacol, 11():1202(2020) [pubmed]
10.3389/fphar.2020.01202;
Keyword List
submitter keyword: proteomics,Agarikon, TMT, medicinal mushroom supplement, advanced colorectal cancer, Balb/c mice, animal model
Contact List
Peter David Eckersall
contact affiliationVetMedZg Laboratory,Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia Institute of Biodiversity, Animal Health & Comparative Medicine, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, UK
contact emailDavid.Eckersall@glasgow.ac.uk
lab head
Anita Horvatic
contact affiliationUniversity of Zagreb, Faculty of Veterinary Medicine
contact emailhorvatic.ani@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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