PXD018827 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic investigation of treatment with medicinal mushroom supplement Agarikon.1® in advanced colorectal cancer animal model |
Description | Colorectal cancer (CRC) is the third most frequent cancer type in both males and females, with about 35% of patients being diagnosed in stage IV metastatic disease. Despite advancements in treatment, life expectancy in patients with metastatic disease is low. Due to frequent drug resistance during conventional and targeted cancer treatments, the development and testing of multi-target therapies is an important objective. Medicinal mushrooms specific compound isolates as well as complex extract mixtures have been studied in depth, and many mushroom species have been proven to be non-toxic multi-target inhibitors of specific oncogenic pathways, as well as potent immunomodulators. In this study, we have performed a tandem mass tags qualitative and quantitative proteomic analyses of CT26.WT colon cancer tumor tissues from Balb/c mice treated with proprietary medicinal mushroom extract Agarikon.1®, with or without 5-fluorouracil. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:14:18.177.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Anita Horvatic |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive Plus |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-04-27 03:51:31 | ID requested | |
1 | 2020-10-27 03:22:21 | announced | |
⏵ 2 | 2024-10-22 05:14:19 | announced | 2024-10-22: Updated project metadata. |
Publication List
Jakopovic B, Horvati, ć A, Klobu, č, ar M, Gelemanovi, ć A, Grb, č, i, ć P, Or, š, oli, ć N, Jakopovich I, Kraljevi, ć, Paveli, ć S, Treatment With Medicinal Mushroom Extract Mixture Inhibits Translation and Reprograms Metabolism in Advanced Colorectal Cancer Animal Model as Evidenced by Tandem Mass Tags Proteomics Analysis. Front Pharmacol, 11():1202(2020) [pubmed] |
10.3389/fphar.2020.01202; |
Keyword List
submitter keyword: proteomics,Agarikon, TMT, medicinal mushroom supplement, advanced colorectal cancer, Balb/c mice, animal model |
Contact List
Peter David Eckersall |
contact affiliation | VetMedZg Laboratory,Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia Institute of Biodiversity, Animal Health & Comparative Medicine, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, UK |
contact email | David.Eckersall@glasgow.ac.uk |
lab head | |
Anita Horvatic |
contact affiliation | University of Zagreb, Faculty of Veterinary Medicine |
contact email | horvatic.ani@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/10/PXD018827 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD018827
- Label: PRIDE project
- Name: Proteomic investigation of treatment with medicinal mushroom supplement Agarikon.1® in advanced colorectal cancer animal model