PXD018809

PXD018809 is an original dataset announced via ProteomeXchange.

Title	Staphylococcus aureus membrane vesicles confer resistance to antimicrobial fatty acids
Description	S. aureus is a common commensal inhabitant of skin and nares of healthy individuals. In these environments, S. aureus overcomes colonisation barriers deployed by the innate immune system, which include long chain unsaturated free fatty acids with known potent anti-staphylococcal activity. S. aureus resistance mechanisms to these antimicrobial fatty acids (AFAs) remain elusive. However, it is well-documented that AFAs target S. aureus membrane, and increase its fluidity. This is associated with a drastic change in secreted proteins. The most abundantly secreted proteins in response to AFAs were recently identified to be components of S. aureus membrane vesicles (MVs), as revealed by proteomics analyses. Here, we demonstrate that MVs are decoys that trap AFAs. Importantly, MV release and composition are modulated by AFAs to promote bacterial survival.
HostingRepository	PRIDE
AnnounceDate	2021-09-09
AnnouncementXML	Submission_2021-09-08_23:32:54.109.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Nicolas Nalpas
SpeciesList	scientific name: Staphylococcus aureus; NCBI TaxID: 1280;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-04-26 14:46:52	ID requested
⏵ 1	2021-09-08 23:32:54	announced

Kengmo Tchoupa A, Peschel A, Staphylococcus aureus Releases Proinflammatory Membrane Vesicles To Resist Antimicrobial Fatty Acids. mSphere, 5(5):(2020) [pubmed]

submitter keyword: membrane vesicles, innate immunity, antimicrobial fatty acids

Prof. Dr. Andreas Peschel
contact affiliation	Infection Biology Department Interfaculty Institute of Microbiology and Infection Medicine University of Tübingen 72076 Tübingen Germany
contact email	andreas.peschel@uni-tuebingen.de
lab head
Nicolas Nalpas
contact affiliation	Tuebingen University
contact email	nalpas.nicolas@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD018809

PRIDE project URI

• PRIDE
  1. PXD018809
     1. Label: PRIDE project
     2. Name: Staphylococcus aureus membrane vesicles confer resistance to antimicrobial fatty acids