PXD018801

PXD018801 is an original dataset announced via ProteomeXchange.

Title	Highly anti-Trypanosoma brucei activity of ultra-small noble metal nanoclusters via multiple signaling pathways cross-linked apoptosis mechanism
Description	African trypanosomiasis is still one of the infectious diseases threatening the health of human beings and animals, and severely impeding the continental economic development. Currently, the disease control programs are mainly relying on a limited number of parasiticides which are either expensive or with severe side-effect, and insecticides. In this study, we investigated the anti-trypanosome effect of two noble metal nanoclusters (NM-NCs), Ag2S-NC@MPA and AuNC@GSH. Both types of NCs can be efficiently up-taken by Trypanosoma brucei via a clathrin-dependent endocytosis pathway, and displayed dose-dependent anti-parasite effect by inducing apoptosis-associated organelle pathological alterations. The data not only revealed the clathrin-dependent endocytosis pathway in African trypanosome, but also proposed a new avenue for NM-NC-based drug development for trypanosomiasis.
HostingRepository	iProX
AnnounceDate	2020-04-26
AnnouncementXML	Submission_2020-04-26_02:46:03.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Di Zhang
SpeciesList	scientific name: Trypanosoma brucei; NCBI TaxID: 5691;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2020-04-26 02:44:36	ID requested
⏵ 1	2020-04-26 02:46:33	announced

Dataset with its publication pending

submitter keyword: nanobiological effects, noble metal nanoclusters, Trypanosoma brucei, apoptosis, endocytosis

Xinyi Wang
contact affiliation	Shenyang Agricultural University
contact email	wangxy@syau.edu.cn
lab head
Di Zhang
contact affiliation	Shenyang Agricultural University
contact email	785656760@qq.com
dataset submitter

iProX dataset URI