PXD018784

PXD018784 is an original dataset announced via ProteomeXchange.

Title	Characterization of PITH domain-containing protein 1 (C1orf128) functionality in olfactory metabolism
Description	Taking into account the relevance of the smell sense in the early diagnosis of neurodegenerative diseases, we have analyzed the expression profile of the dark proteome across public proteomic and transcriptomic data derived from primary olfactory areas such as olfactory bulb (OB) and cleft mucus as well as from specific brain/OB cell linages. In this study, we have used an experimental workflow combining neuropathological diagnosis, co-regulation maps, physical and functional interaction data, transgenic models, intracellular and extracellular proteomics and immunohistochemical and biochemical approaches to partially decipher the UPE1 PITHD1 function in olfactory metabolism.
HostingRepository	PRIDE
AnnounceDate	2020-11-19
AnnouncementXML	Submission_2020-11-19_06:43:10.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD018784
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Mikel Azkargorta
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; TMT6plex; Oxidation; Carbamidomethyl
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2020-04-24 02:40:31	ID requested
⏵ 1	2020-11-19 06:43:11	announced

Lach, é, n-Montes M, Mendizuri N, Aus, í, n K, P, é, rez-Mediavilla A, Azkargorta M, Iloro I, Elortza F, Kondo H, Ohigashi I, Ferrer I, de la Torre R, Robledo P, Fern, á, ndez-Irigoyen J, Santamar, í, a E, Smelling the Dark Proteome: Functional Characterization of PITH Domain-Containing Protein 1 (C1orf128) in Olfactory Metabolism. J Proteome Res, 19(12):4826-4843(2020) [pubmed]

ProteomeXchange project tag: Human Brain Proteome Project (HUPO_HBPP) (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project

submitter keyword: HPP, TMT, TIMStof, PITHD1

Felix Elortza
contact affiliation	Proteomics Service, CIC bioGUNE, Build. 800 Bizkaia Tech. Park, Zamudio, Spain
contact email	felortza@cicbiogune.es
lab head
Mikel Azkargorta
contact affiliation	Proteomics Platform CIC bioGUNE
contact email	mazkargorta@cicbiogune.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/11/PXD018784

PRIDE project URI

• PRIDE
  1. PXD018784
     1. Label: PRIDE project
     2. Name: Characterization of PITH domain-containing protein 1 (C1orf128) functionality in olfactory metabolism