PXD018757

PXD018757 is an original dataset announced via ProteomeXchange.

Title	Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration
Description	This study sought to explore phosphoproteome signaling dysregulation in different models of neurodegeneration. We collected phosphotyrosine, MAPK/CDK substrates, global phosphoproteome, and protein expression data from hippocampus and/or cortex tissue from each model. Tryptic peptides were multiplexd with TMT, enriched for phosphopeptides, and then identified and quantified by LC-MS/MS. We additionally quantified phosphotyrosine peptides from BV-2 cells expressing various Siglec receptor constructs.
HostingRepository	PRIDE
AnnounceDate	2024-10-08
AnnouncementXML	Submission_2024-10-08_11:12:43.439.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD018757
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Nader Morshed
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; Phospho; TMT6plex; phosphorylated residue; Oxidation; monohydroxylated residue; Carbamidomethyl; iodoacetamide derivatized residue
Instrument	Q Exactive; LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2020-04-23 01:03:18	ID requested
⏵ 1	2024-10-08 11:12:43	announced

10.6019/PXD018757;

submitter keyword: Tau P301S, Siglec-F, Mouse, 5XFAD, BV-2, phosphotyrosine,Alzheimer's disease, CK-p25, LC-MS/MS

Forest Michael White
contact affiliation	Department of Biological Engineering, Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA
contact email	fwhite@mit.edu
lab head
Nader Morshed
contact affiliation	Massachusetts Institute of Technology
contact email	morshed@mit.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/11/PXD018757

PRIDE project URI

• PRIDE
  1. PXD018757
     1. Label: PRIDE project
     2. Name: Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration