PXD018736

PXD018736 is an original dataset announced via ProteomeXchange.

Title	Characterization of human aging and Parkinson’s disease pre-frontal cortex by multi-omics: a glycomics, proteomics study.
Description	This study identifies the age and PD related changes in glycans (HS and CS disaccharides) and proteomics in human aging and Parkinson’s disease. We analyzed the prefrontal cortex for changes in HS, CS and proteomic signatures in young versus aged as well as aged and PD in two cohorts. These studies provide insight into age- and PD changes in glycans and proteomics. We assess changes with PD and observe for pathways that may correlate with transcriptomics. We also observe in aging related proteomic changes and transcriptomics for changes in common with PD that may describe risk of disease.
HostingRepository	PRIDE
AnnounceDate	2020-07-16
AnnouncementXML	Submission_2020-07-16_06:28:04.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rekha Raghunathan
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-04-22 06:31:02	ID requested
⏵ 1	2020-07-16 06:28:04	announced

Dataset with its publication pending

submitter keyword: glycomic, proteomic, label-free proteomics, heparan sulfate, chondroitin sulfate, aging, Parkinson’s disease, pre-frontal cortex, multi-omics, mass spectrometry, hilic-wax, reverse phase, LC-MSMS.

Joseph Zaia
contact affiliation	Biochemistry, Boston University
contact email	jzaia@bu.edu
lab head
Rekha Raghunathan
contact affiliation	Boston University
contact email	rrekha@bu.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/07/PXD018736

PRIDE project URI

• PRIDE
  1. PXD018736
     1. Label: PRIDE project
     2. Name: Characterization of human aging and Parkinson’s disease pre-frontal cortex by multi-omics: a glycomics, proteomics study.