PXD018726

PXD018726 is an original dataset announced via ProteomeXchange.

Title	Proteomic Investigations of Two Pakistani Naja Snake Venoms Species Unravel the Venom Complexity, Posttranslational Modifications and Presence of Extracellular Vesicles
Description	Latest advancement of omics technologies allows in-depth characterization of venom compositions. In the present work we present a proteomic study of two snake venoms of the genus Naja i.e. Naja naja (black cobra) and Naja oxiana (brown cobra), of Pakistani origin. The present study has shown that these snake venoms consist of a highly diversified proteome. Furthermore, the data also revealed variation among closely related species. High throughput mass spectrometric analysis of the venom proteome allowed to identify for the N. naja venom 34 protein families and for the N. oxiana 24 protein families. The comparative evaluation of the two venoms showed that N. naja consists of a more complex venom proteome than N. oxiana venom.
HostingRepository	PRIDE
AnnounceDate	2020-10-29
AnnouncementXML	Submission_2020-10-29_01:20:53.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD018726
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Benjamin Dreyer
SpeciesList	scientific name: Naja naja; NCBI TaxID: 35670; scientific name: Naja oxiana; NCBI TaxID: 8657;
ModificationList	Met-loss; Deamidated; 2-pyrrolidone-5-carboxylic acid (Gln); Oxidation; Acetyl; monohydroxylated residue; N-acetylated residue; Carbamidomethyl; iodoacetamide derivatized residue; deamidated residue; Gln->pyro-Glu
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-04-22 01:23:44	ID requested
⏵ 1	2020-10-29 01:20:54	announced

Manuwar A, Dreyer B, B, ö, hmert A, Ullah A, Mughal Z, Akrem A, Ali SA, Schl, ü, ter H, Betzel C, Snake Venoms Species Unravel the Venom Complexity, Posttranslational Modifications, and Presence of Extracellular Vesicles. Toxins (Basel), 12(11):(2020) [pubmed]

submitter keyword: Naja naja

Naja oxiana

venom proteome;

Hartmut Schlüter
contact affiliation	University Medical Center Hamburg-Eppendorf: Hamburg, Hamburg, DE, Institute of Clinical Chemistry and Laboratory Medicine, Mass Spectrometric Proteomics
contact email	h.schlueter@uke.de
lab head
Benjamin Dreyer
contact affiliation	University Medical Center Hamburg-Eppendorf, Institute of Clinical Chemistry and Laboratory Medicine, Mass Spectrometric Proteomics
contact email	b.dreyer@uke.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/10/PXD018726

PRIDE project URI

• PRIDE
  1. PXD018726
     1. Label: PRIDE project
     2. Name: Proteomic Investigations of Two Pakistani Naja Snake Venoms Species Unravel the Venom Complexity, Posttranslational Modifications and Presence of Extracellular Vesicles