<<< Full experiment listing


PXD018712 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe Human Telomeric Proteome During Telomere Replication
DescriptionTelomere shortening can cause detrimental diseases and contribute to aging. It occurs due to the end replication problem in cells lacking telomerase. In addition, recent evidence revealed that telomere shortening can be attributed to difficulties of the semi-conservative DNA replication machinery to replicate through the bulk of telomeric DNA repeats. To investigate telomere replication in a comprehensive manner, we developed QTIP-iPOND, which enables purification of the proteins that associate with telomeres during their replication. We identify in addition to the core replisome a large number of proteins that specifically associate with telomere replication forks and validate their importance.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterChih-Yi Gabriela Lin
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-04-21 08:44:52ID requested
12021-11-03 06:19:19announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: QTIP, iPOND, telomeres, DNA replication, telomere fragility, histone H1, POT1
Contact List
Joachim Lingner
contact affiliationSwiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
contact emailjoachim.lingner@epfl.ch
lab head
Chih-Yi Gabriela Lin
contact affiliationEPFL
contact emailchih-yi.lin@epfl.ch
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/11/PXD018712
PRIDE project URI
Repository Record List
[ + ]