PXD018709

PXD018709 is an original dataset announced via ProteomeXchange.

Title	Nuclear Estrogen Receptor alpha (ERα) interactome following estrogen and antiestrogen treatment.
Description	The Estrogen Receptor alpha (ERα) controls key cellular functions in hormone responsive breast cancer by assembling in large functional multiprotein complexes. ERα ligands are classified as agonists and antagonist, according to the response they elicit, thus the molecular characterization of the of ERα nuclear iteractome composition following estrogen and antiestrogen stimulation whose is needed to understand their effects on estrogen target tissues, in particular breast cancer. To this aim interaction proteomics coupled to mass spectrometry (MS) was applied to map the ERα nuclear interacting partners in MCF7 breast cancer cell nuclei following estrogen and antiestrogen stimuli.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:11:42.584.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tuula Nyman
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-04-21 05:34:21	ID requested
1	2020-09-02 07:06:12	announced
⏵ 2	2024-10-22 05:11:43	announced	2024-10-22: Updated project metadata.

Gigantino V, Salvati A, Giurato G, Palumbo D, Strianese O, Rizzo F, Tarallo R, Nyman TA, Weisz A, Nassa G, Interactomes in Hormone-Responsive Human Breast Cancer Cell Nuclei. Proteomics, 20(19-20):e2000135(2020) [pubmed]

10.1002/pmic.202000135;

submitter keyword: estrogen and antiestrogen signaling, Interaction proteomics,Estrogen Receptor alpha (ERα)

Tuula Nyman
contact affiliation	Head of Proteomics
contact email	tuula.nyman@medisin.uio.no
lab head
Tuula Nyman
contact affiliation	University of Oslo
contact email	tuula.nyman@medisin.uio.no
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/09/PXD018709

PRIDE project URI

• PRIDE
  1. PXD018709
     1. Label: PRIDE project
     2. Name: Nuclear Estrogen Receptor alpha (ERα) interactome following estrogen and antiestrogen treatment.