PXD018687
PXD018687 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Physiological tau interactome in brain and its link to tauopathies_complete submission |
| Description | Alzheimer's disease (AD) and most of other tauopathies are incurable neurodegenerative diseases with unpleasant symptoms and consequences. The common hallmark of all these diseases is tau pathology but its connection with disease progress has not been completely understood so far. Therefore, uncovering novel tau interacting partners and pathology affected molecular pathways can reveal the causes of diseases as well as potential targets for development of AD treatment. Despite of large amount of known tau interacting partners, limited number of studies focused on in vivo tau interactions in disease or healthy conditions are available. Here, we applied an in vivo crosslinking approach, capable of capturing weak and transient protein-protein interactions, to a unique transgenic rat model of progressive tau pathology similar to human AD. We have identified 175 potential novel and known tau interacting proteins by MALDI-TOF mass spectrometry. Several of the most promising candidates for potential drug development were selected for validation by coimmunoprecipitation and colocalization experiments in animal and cellular models. |
| HostingRepository | PRIDE |
| AnnounceDate | 2024-10-07 |
| AnnouncementXML | Submission_2024-10-07_10:39:47.138.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD018687 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Jozef Hanes |
| SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; |
| ModificationList | Deamidated; Formyl; Oxidation; Carbamidomethyl; formylated residue; iodoacetamide derivatized residue; deamidated residue |
| Instrument | ultraflex |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2020-04-20 08:45:32 | ID requested | |
| ⏵ 1 | 2024-10-07 10:39:47 | announced |
Publication List
| Sinsky J, Majerova P, Kovac A, Kotlyar M, Jurisica I, Hanes J, Physiological Tau Interactome in Brain and Its Link to Tauopathies. J Proteome Res, 19(6):2429-2442(2020) [pubmed] |
| 10.1021/acs.jproteome.0c00137; |
| 10.6019/PXD018687; |
Keyword List
| submitter keyword: mass spectrometry, Alzheimer's disease, in vivo crosslinking, tau interaction partners,tau protein, tauopathies, tau pathology |
Contact List
| Dr. Andrej Kovac | |
|---|---|
| contact affiliation | Laboratory of Proteomics and Metabolomics, Institute of Neuroimmunology, Slovak Academy of Sciences, Dubravska cesta 9, 84510, Bratislava, Slovakia |
| contact email | andrej.kovac@savba.sk |
| lab head | |
| Jozef Hanes | |
| contact affiliation | Institute of Neuroimmunology, Slovak Academy of Sciences, Dubravska cesta 9, 84510, Bratislava, Slovakia |
| contact email | jozef.hanes@savba.sk |
| dataset submitter | |
Full Dataset Link List
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/05/PXD018687 |
| PRIDE project URI |
Repository Record List
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