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PXD018678

PXD018678 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic analysis of ischemic and dilated cardiomyopathy pre-mortem human hearts
DescriptionOur understanding of heart failure (HF) has been provided by indirect surrogates, such as post-mortem histology, cardiovascular imaging, and molecular characterisation in vivo and in vitro, rather than directly in pre-mortem human cardiac tissue. Using our heart bank of pre-mortem hearts procured according to the most stringent protocols, we examined ischemic (ICM) and dilated cardiomyopathy (DCM) -- the most common causes of HF and leading causes of cardiac transplantation1. We performed unbiased, comprehensive, paired proteomic and metabolomic analysis of 51 left ventricular (LV) samples from 44 cryopreserved pre-mortem human ICM and DCM hearts, including age-matched, healthy, histopathologically-normal donor controls of both genders for comparison. Data integration via pathway and correlation network analysis revealed overlapping and divergent disease pathways in ICM and DCM, and, strikingly, precise sex-specific differences within each disease that unveil the interaction of gender with HF. Identified core functional nodes in each disease may serve as novel therapeutic targets, and we provide all proteomic and metabolomic results via an interactive online repository (https://mengboli.shinyapps.io/heartomics/) as a publicly available resource.
HostingRepositoryPRIDE
AnnounceDate2023-09-28
AnnouncementXMLSubmission_2023-09-28_09:26:04.874.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterBenjaminParker
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF-X
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-04-20 07:36:26ID requested
12020-05-01 06:39:56announced
22023-09-28 09:26:05announced2023-09-28: Updated project metadata.
Publication List
Li M, Parker BL, Pearson E, Hunter B, Cao J, Koay YC, Guneratne O, James DE, Yang J, Lal S, O'Sullivan JF, Core functional nodes and sex-specific pathways in human ischaemic and dilated cardiomyopathy. Nat Commun, 11(1):2843(2020) [pubmed]
Keyword List
submitter keyword: ischemic cardiomyopathy,myocardium, dilated cardiomyopathy
Contact List
BenjaminParker
contact affiliationThe University of Melbourne
contact emailben.parker@unimelb.edu.au
lab head
BenjaminParker
contact affiliationThe University of Melbourne
contact emailben.parker@unimelb.edu.au
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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