PXD018678 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic analysis of ischemic and dilated cardiomyopathy pre-mortem human hearts |
Description | Our understanding of heart failure (HF) has been provided by indirect surrogates, such as post-mortem histology, cardiovascular imaging, and molecular characterisation in vivo and in vitro, rather than directly in pre-mortem human cardiac tissue. Using our heart bank of pre-mortem hearts procured according to the most stringent protocols, we examined ischemic (ICM) and dilated cardiomyopathy (DCM) -- the most common causes of HF and leading causes of cardiac transplantation1. We performed unbiased, comprehensive, paired proteomic and metabolomic analysis of 51 left ventricular (LV) samples from 44 cryopreserved pre-mortem human ICM and DCM hearts, including age-matched, healthy, histopathologically-normal donor controls of both genders for comparison. Data integration via pathway and correlation network analysis revealed overlapping and divergent disease pathways in ICM and DCM, and, strikingly, precise sex-specific differences within each disease that unveil the interaction of gender with HF. Identified core functional nodes in each disease may serve as novel therapeutic targets, and we provide all proteomic and metabolomic results via an interactive online repository (https://mengboli.shinyapps.io/heartomics/) as a publicly available resource. |
HostingRepository | PRIDE |
AnnounceDate | 2023-09-28 |
AnnouncementXML | Submission_2023-09-28_09:26:04.874.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | BenjaminParker |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF-X |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-04-20 07:36:26 | ID requested | |
1 | 2020-05-01 06:39:56 | announced | |
⏵ 2 | 2023-09-28 09:26:05 | announced | 2023-09-28: Updated project metadata. |
Publication List
Li M, Parker BL, Pearson E, Hunter B, Cao J, Koay YC, Guneratne O, James DE, Yang J, Lal S, O'Sullivan JF, Core functional nodes and sex-specific pathways in human ischaemic and dilated cardiomyopathy. Nat Commun, 11(1):2843(2020) [pubmed] |
Keyword List
submitter keyword: ischemic cardiomyopathy,myocardium, dilated cardiomyopathy |
Contact List
BenjaminParker |
contact affiliation | The University of Melbourne |
contact email | ben.parker@unimelb.edu.au |
lab head | |
BenjaminParker |
contact affiliation | The University of Melbourne |
contact email | ben.parker@unimelb.edu.au |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD018678
- Label: PRIDE project
- Name: Proteomic analysis of ischemic and dilated cardiomyopathy pre-mortem human hearts