PXD018674

PXD018674 is an original dataset announced via ProteomeXchange.

Title	PROTAC-triggered degradation of MYC
Description	The oncogene MYC drives many cancers and is an outstanding therapeutic target. MYC is an intrinsically disordered protein, and therefore, targeting MYC remains a challenge. Here, we developed a proteolysis targeting chimera (PROTAC) degrading MYC: MDEG-541. The inhibitor is based on the MYC-MAX dimerization inhibitor 10058-F4 and Thalidomide. Mode of action depends on the proteasome and cereblon. MDEG-541 shows single digit mM activity in most sensitive colon and pancreatic cancer cell lines as well as gastrointestinal tumor organoids.
HostingRepository	PRIDE
AnnounceDate	2022-05-12
AnnouncementXML	Submission_2022-05-11_21:17:54.579.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Stephanie Heinzlmeir
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2020-04-20 06:25:19	ID requested
⏵ 1	2022-05-11 21:17:55	announced

Lier S, Sellmer A, Orben F, Heinzlmeir S, Krau, ß L, Schneeweis C, Hassan Z, Schneider C, Patricia Gloria Sch, ä, fer A, Pongratz H, Engleitner T, Ö, llinger R, Kuisl A, Bassermann F, Schlag C, Kong B, Dove S, Kuster B, Rad R, Reichert M, Wirth M, Saur D, Mahboobi S, Schneider G, A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer. Bioorg Chem, 119():105505(2022) [pubmed]

submitter keyword: human, MYC degradation, LC-MS3

Prof. Dr. Bernhard Kuster
contact affiliation	Technical University of Munich Chair of Proteomics and Bioanalytics Emil-Erlenmeyer-Forum 5 85354 Freising Germany
contact email	kuster@tum.de
lab head
Stephanie Heinzlmeir
contact affiliation	Chair of Proteomics and Bioanalytics, Technische Universität München, Germany
contact email	stephanie.heinzlmeir@tum.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD018674

PRIDE project URI

• PRIDE
  1. PXD018674
     1. Label: PRIDE project
     2. Name: PROTAC-triggered degradation of MYC