PXD018629

PXD018629 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Phosphorylated Tau Interactome in the Human Alzheimers Disease Brain
Description	Accumulation of phosphorylated tau is a key pathological feature of Alzheimers disease. Phosphorylated tau accumulation causes synaptic impairment, neuronal dysfunction and formation of neurofibrillary tangles. The pathological actions of phosphorylated tau are mediated by surrounding neuronal proteins, however a comprehensive understanding of the proteins that phosphorylated tau interacts with in Alzheimers disease is surprisingly limited. Therefore, the aim of this study was to determine the phosphorylated tau interactome for the first time. To do this we used two complementary proteomics approaches: First, quantitative proteomics was performed on neurofibrillary tangles microdissected from patients with advanced Alzheimers disease. Second, affinity purification-mass spectrometry was used to identify which of these proteins specifically bound to phosphorylated tau.
HostingRepository	MassIVE
AnnounceDate	2020-09-04
AnnouncementXML	Submission_2020-09-04_08:19:27.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Beatrix Ueberheide
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	Phospho
Instrument	Q Exactive; Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2020-04-17 13:11:35	ID requested
⏵ 1	2020-09-04 08:19:28	announced

Publication List

Drummond E, Pires G, MacMurray C, Askenazi M, Nayak S, Bourdon M, Safar J, Ueberheide B, Wisniewski T, Phosphorylated tau interactome in the human Alzheimer's disease brain. Brain, 143(9):2803-2817(2020) [pubmed]

Drummond E, Pires G, MacMurray C, Askenazi M, Nayak S, Bourdon M, Safar J, Ueberheide B, Wisniewski T, Phosphorylated tau interactome in the human Alzheimer's disease brain. Brain, 143(9):2803-2817(2020) [pubmed]

Keyword List

submitter keyword: Tau , neurofibrillary tangles, affinity purifications, laser capture microdissection, label-free, AD

submitter keyword: Tau , neurofibrillary tangles, affinity purifications, laser capture microdissection, label-free, AD

Contact List

Beatrix Ueberheide
contact affiliation	NYU School of Medicine
contact email	beatrix.ueberheide@nyulangone.org
lab head
Beatrix Ueberheide
contact affiliation	NYU School of Medicine
contact email	beatrixueberheide@gmail.com
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000085305/