PXD018606

PXD018606 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Defective insulin receptor signaling in hPSCs skews pluripotency and negatively perturbs neural differentiation
Description	Proteomics and phosphoproteomics analyses of two human pluripotent stem cell (hPSC) lines with stable insulin receptor knock down. 6-plex TMT-based strategy was applied to compare control versus insulin receptor (IR) knockdown (n=3 replicates for each condition) for each cell lines (CHB8 and H9). Data was searched with MS-GF+ using PNNL's DMS Processing pipeline.
HostingRepository	MassIVE
AnnounceDate	2022-08-16
AnnouncementXML	Submission_2022-08-16_09:42:40.577.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Matthew Monroe
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	TMT6plex; Carbamidomethyl; Phospho; Oxidation
Instrument	LTQ Orbitrap Velos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2020-04-16 18:10:03	ID requested
⏵ 1	2022-08-16 09:42:41	announced

Publication List

Teo AKK, Nguyen L, Gupta MK, Lau HH, Loo LSW, Jackson N, Lim CS, Mallard W, Gritsenko MA, Rinn JL, Smith RD, Qian WJ, Kulkarni RN, Defective insulin receptor signaling in hPSCs skews pluripotency and negatively perturbs neural differentiation. J Biol Chem, 296():100495(2021) [pubmed]

Teo AKK, Nguyen L, Gupta MK, Lau HH, Loo LSW, Jackson N, Lim CS, Mallard W, Gritsenko MA, Rinn JL, Smith RD, Qian WJ, Kulkarni RN, Defective insulin receptor signaling in hPSCs skews pluripotency and negatively perturbs neural differentiation. J Biol Chem, 296():100495(2021) [pubmed]

Keyword List

submitter keyword: pluripotent, stem cells, insulin receptor signaling

submitter keyword: pluripotent, stem cells, insulin receptor signaling

Contact List

Wei-Jun Qian
contact affiliation	Pacific Northwest National Laboratory
contact email	Weijun.Qian@pnnl.gov
lab head
Matthew Monroe
contact affiliation	Pacific Northwest National Laboratory
contact email	matthew.monroe@pnnl.gov
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000085298/