PXD018603

PXD018603 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Targeting LSD1 rewires kinase networks and primes leukaemia cells for kinase inhibitor treatment
Description	We show that intrinsic resistance to kinase inhibitors may be reversed by coercing kinase networks into acquiring topologies tolerant to drug sensitivity. Using acute myeloid leukaemia (AML) as a model, we found several antagonists of chromatin modifying enzymes that sensitised cancer cells to kinase inhibitor treatments.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:50:51.293.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD018603
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Maruan Hijazi
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Phospho; Oxidation; Carbamidomethyl; Gln->pyro-Glu
Instrument	Q Exactive Plus

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2020-04-16 08:48:45	ID requested
1	2022-04-25 19:21:31	announced
⏵ 2	2023-11-14 08:50:51	announced	2023-11-14: Updated project metadata.

Publication List

10.6019/PXD018603;

10.6019/PXD018603;

Keyword List

submitter keyword: phosphoproteomics, kinase signaling networks, LSD1, acute myeloid leukaemia, bioinformatics

submitter keyword: phosphoproteomics, kinase signaling networks, LSD1, acute myeloid leukaemia, bioinformatics

Contact List

Pedro Cutillas
contact affiliation	Barts Cancer Institute. Queen Mary University of London
contact email	p.cutillas@qmul.ac.uk
lab head
Maruan Hijazi
contact affiliation	University of Salamanca
contact email	m.hijazivega@qmul.ac.uk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD018603
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD018603

PRIDE project URI

Repository Record List

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