PXD018597

PXD018597 is an original dataset announced via ProteomeXchange.

Title	Myeloid PTEN promotes chemotherapy-induced NLRP3 inflammasome activation and antitumor immunity
Description	In this study, we found that myeloid PTEN can determine chemotherapy responsiveness by promoting NLRP3-dependent antitumor immunity and suggest that it might be a potential biomarker to predict the chemotherapy responses and manipulating NLRP3/IL-1might be able to overcome the chemotherapy resistance in PTEN-loss patients.
HostingRepository	iProX
AnnounceDate	2020-04-16
AnnouncementXML	Submission_2020-11-24_22:05:09.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yi Huang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2020-04-16 04:54:50	ID requested
1	2020-04-16 04:58:15	announced
⏵ 2	2020-11-24 22:05:10	announced	2020-11-25: Update publication information

Huang Y, Wang H, Hao Y, Lin H, Dong M, Ye J, Song L, Wang Y, Li Q, Shan B, Jiang Y, Li H, Shao Z, Kroemer G, Zhang H, Bai L, Jin T, Wang C, Ma Y, Cai Y, Ding C, Liu S, Pan Y, Jiang W, Zhou R, Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity. Nat Cell Biol, 22(6):716-727(2020) [pubmed]

submitter keyword: Myeloid PTEN, chemotherapy, NLRP3 inflammasome

Rongbin Zhou
contact affiliation	University of Science and Technology of China
contact email	zrb1980@ustc.edu.cn
lab head
Yi Huang
contact affiliation	University of Science and Technology of China
contact email	hy527@mail.ustc.edu.cn
dataset submitter

iProX dataset URI