PXD018593
PXD018593 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Quantitative proteomic data of hepatocellular carcinoma |
| Description | Ubiquitination plays a critical role in human cancer genesis and metastasis, but how the systemic ubiquitinome changes during these processes remains unclear. In this study, our dataset of approximately 12,000 identified ubiquitinated sites provided valuable insight into human hepatocellular carcinoma (HCC). We found that both the ubiquitinated sites and ubiquitin chains were obviously increased in HCC, thereby suggesting ubiquitination was related to tumorigenesis. The ubiquitination of proteins involved in antigen processing and presentation occupied a vital position in HCC genesis. Moreover, during the progression of HCC metastasis, we discovered increased ubiquitinated sites with shorter ubiquitin chains, which might have resulted from monoubiquitination and revealed the key role of ubiquitination on proteins involved in cell-cell adhesion. |
| HostingRepository | iProX |
| AnnounceDate | 2020-04-16 |
| AnnouncementXML | Submission_2023-03-01_18:28:52.618.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Feiyang Ji |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2020-04-15 21:00:54 | ID requested | |
| 1 | 2021-01-03 21:56:34 | announced | |
| ⏵ 2 | 2023-03-01 18:28:53 | announced | 2023-03-02: Update publication information. |
Publication List
| Ji F, Zhou M, Sun Z, Jiang Z, Zhu H, Xie Z, Ouyang X, Zhang L, Li L, Integrative proteomics reveals the role of E3 ubiquitin ligase SYVN1 in hepatocellular carcinoma metastasis. Cancer Commun (Lond), 41(10):1007-1023(2021) [pubmed] |
Keyword List
| submitter keyword: hepatocellular carcinoma, whole cell proteome |
Contact List
| Lanjuan Li | |
|---|---|
| contact affiliation | Zhejiang University |
| contact email | ljli@zju.edu.cn |
| lab head | |
| Feiyang Ji | |
| contact affiliation | Zhejiang University |
| contact email | feiyangji@zju.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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